Literature DB >> 356971

Phase II study of vinblastine, methyl-CCNU, and medroxyprogesterone in advanced renal cell cancer.

R G Hahn, N R Temkin, E D Savlov, C Perlia, G L Wampler, J Horton, J Marsh, P P Carbone.   

Abstract

One hundred and sixty-five patients with advanced renal cell cancer were evaluable for combination or single-agent therapy with methyl-CCNU, vinblastine, and medroxyprogesterone. A low order or response was observed, and these agents were not proven effective as treatment for metastatic renal cell cancer. Performance status and a relatively long symptom-free interval from primary tumor to metastatic disease were found to be the most prognostically significant factors for survival.

Entities:  

Keywords:  Biology; Cancer; Clinic Activities; Clinical Research; Contraception; Contraceptive Agents, Female--therapeutic use; Contraceptive Agents, Progestin--therapeutic use; Contraceptive Agents--therapeutic use; Diseases; Family Planning; Medroxyprogesterone Acetate--therapeutic use; Neoplasms; Physiology; Prospective Studies; Renal Effects; Research Methodology; Studies; Treatment; Urogenital Effects; Urogenital System

Mesh:

Substances:

Year:  1978        PMID: 356971

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN: 0361-5960


  3 in total

1.  A phase II trial of amonafide, caracemide, and homoharringtonine in the treatment of patients with advanced renal cell cancer.

Authors:  R S Witte; P Hsieh; P Elson; M M Oken; D L Trump
Journal:  Invest New Drugs       Date:  1996       Impact factor: 3.850

2.  Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.

Authors:  P J Elson; L K Kvols; S E Vogl; D J Glover; R G Hahn; D L Trump; P P Carbone; J D Earle; T E Davis
Journal:  Invest New Drugs       Date:  1988-06       Impact factor: 3.850

3.  Trimetrexate in advanced renal cell carcinoma. An ECOG phase II trial.

Authors:  R S Witte; P Elson; G T Bryan; D L Trump
Journal:  Invest New Drugs       Date:  1992-04       Impact factor: 3.850

  3 in total

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