Literature DB >> 3569528

Ca2+/calmodulin-dependent phosphorylation of elongation factor 2.

A G Ryazanov.   

Abstract

Incubation of a ribosome-free extract of rabbit reticulocytes or rat liver with [gamma-32P]ATP and Ca2+ results in incorporation of 32P predominantly into a single polypeptide of Mr approximately 100,000. This polypeptide is identified as elongation factor 2 (EF-2). Phosphorylation of EF-2 is strictly Ca2+-dependent and can be inhibited by the calmodulin antagonist trifluoperazine. It is suggested that the Ca2+/calmodulin-dependent phosphorylation of EF-2 is involved in regulation of protein biosynthesis.

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Year:  1987        PMID： 3569528     DOI： 10.1016/0014-5793(87)80081-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  41 in total

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Authors:  P Marin; K L Nastiuk; N Daniel; J A Girault; A J Czernik; J Glowinski; A C Nairn; J Prémont
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

Review 2.  The molecular bases of training adaptation.

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3.  Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway.

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Review 4.  The plant translational apparatus.

Authors:  K S Browning
Journal:  Plant Mol Biol       Date:  1996-10       Impact factor: 4.076

5.  The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.

Authors:  N T Redpath; C G Proud
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

6.  Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase.

Authors:  Nathan Will; Andrea Piserchio; Isaac Snyder; Scarlet B Ferguson; David H Giles; Kevin N Dalby; Ranajeet Ghose
Journal:  Biochemistry       Date:  2016-09-14       Impact factor: 3.162

7.  Inhibition of protein synthesis in intact mammalian cells by arachidonic acid.

Authors:  E I Rotman; M A Brostrom; C O Brostrom
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

8.  A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.

Authors:  Adam J Rose; Thomas J Alsted; Thomas E Jensen; J Bjarke Kobberø; Stine J Maarbjerg; Jørgen Jensen; Erik A Richter
Journal:  J Physiol       Date:  2009-02-02       Impact factor: 5.182

9.  Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesis.

Authors:  J E Celis; P Madsen; A G Ryazanov
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

Review 10.  The alpha-kinase family: an exceptional branch on the protein kinase tree.

Authors:  Jeroen Middelbeek; Kristopher Clark; Hanka Venselaar; Martijn A Huynen; Frank N van Leeuwen
Journal:  Cell Mol Life Sci       Date:  2009-12-12       Impact factor: 9.261
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