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Literature DB >> 3569520

Peculiarities of immunoglobulin gene structures as a basis for somatic mutation emergence.

N A Kolchanov, V V Solovyov, I B Rogozin.

Abstract

Using the method of contextual analysis, we have studied the collection of somatic mutations in immunoglobulin genes. It has been found that the emergence of somatic mutations can be based on the reparation of complementarity violations in the heteroduplexes corresponding to complementary palindromes or direct repeats of DNA.

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Year: 1987 PMID： 3569520 DOI： 10.1016/0014-5793(87)80018-2

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

7 in total

Review 1. Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes.

Authors: H S Rothenfluh; R V Blanden; E J Steele
Journal: Immunogenetics Date: 1995 Impact factor: 2.846

2. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.

Authors: B Goyenechea; C Milstein
Journal: Proc Natl Acad Sci U S A Date: 1996-11-26 Impact factor: 11.205

3. Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

Authors: A González-Fernández; S K Gupta; R Pannell; M S Neuberger; C Milstein
Journal: Proc Natl Acad Sci U S A Date: 1994-12-20 Impact factor: 11.205

Peculiarities of immunoglobulin gene structures as a basis for somatic mutation emergence.

Review 1. Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes.

2. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.

3. Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

4. B2-like repetitive sequence from the X chromosome of the American mink (Mustela vison).

5. Genetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity.

6. Quantitative regulation of class switch recombination by switch region transcription.

Review 7. AID to overcome the limitations of genomic information by introducing somatic DNA alterations.