Literature DB >> 3569488

Inactivation of sarin and soman by cyclodextrins in vitro.

B Désiré, S Saint-André.   

Abstract

Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.

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Year:  1987        PMID： 3569488     DOI： 10.1007/bf01940424

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  INCLUSION COMPOUNDS. 18. THE CATALYSIS OF THE FISSION OF PYROPHOSPHATES BY CYCLODEXTRIN. A MODEL REACTION FOR THE MECHANISM OF ENZYMES.

Authors:  N HENNRICH; F CRAMER
Journal:  J Am Chem Soc       Date:  1965-03-05       Impact factor: 15.419

2.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

3.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

4.  Stereospecificity of hydrolytic enzymes on reaction with asymmetric organophosphorus compounds. 3. The inhibition of acetylcholinesterase and butyrylcholinesterase by enantiomeric forms of sarin.

Authors:  H L Boter; C van Dijk
Journal:  Biochem Pharmacol       Date:  1969-10       Impact factor: 5.858

5.  Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman.

Authors:  H P Benschop; C A Konings; J Van Genderen; L P De Jong
Journal:  Toxicol Appl Pharmacol       Date:  1984-01       Impact factor: 4.219

6.  Interaction of soman with beta-cyclodextrin.

Authors:  B Desire; S Saint-Andre
Journal:  Fundam Appl Toxicol       Date:  1986-11

7.  [Inactivation of soman by beta-cyclodextrin].

Authors:  S Saint-André; B Désiré
Journal:  C R Acad Sci III       Date:  1985
  7 in total
  7 in total

1.  Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent.

Authors:  Michael Zengerle; Florian Brandhuber; Christian Schneider; Franz Worek; Georg Reiter; Stefan Kubik
Journal:  Beilstein J Org Chem       Date:  2011-11-22       Impact factor: 2.883

2.  Dose-dependent response to cyclodextrin infusion in a rat model of verapamil toxicity.

Authors:  Allan R Mottram; Sean M Bryant; Steven E Aks
Journal:  West J Emerg Med       Date:  2012-02

3.  Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds.

Authors:  Sophie Letort; Michaël Bosco; Benedetta Cornelio; Frédérique Brégier; Sébastien Daulon; Géraldine Gouhier; François Estour
Journal:  Beilstein J Org Chem       Date:  2017-03-06       Impact factor: 2.883

4.  Comparison of Binding Affinities of Water-Soluble Calixarenes with the Organophosphorus Nerve Agent Soman (GD) and Commonly-Used Nerve Agent Simulants.

Authors:  Jayne A Ede; Peter J Cragg; Mark R Sambrook
Journal:  Molecules       Date:  2018-01-19       Impact factor: 4.411

5.  Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes.

Authors:  Geraldine Magnin; Philippe Bissel; Roberto McAlister Council-Troche; Zhiguo Zhou; Marion Ehrich
Journal:  ACS Omega       Date:  2019-10-28

6.  Advances in toxicology and medical treatment of chemical warfare nerve agents.

Authors:  Mohammd Moshiri; Emadodin Darchini-Maragheh; Mahdi Balali-Mood
Journal:  Daru       Date:  2012-11-28       Impact factor: 3.117

Review 7.  Molecular Recognition of Nerve Agents and Their Organophosphorus Surrogates: Toward Supramolecular Scavengers and Catalysts.

Authors:  Tyler J Finnegan; Vageesha W Liyana Gunawardana; Jovica D Badjić
Journal:  Chemistry       Date:  2021-08-10       Impact factor: 5.020
  7 in total

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