Literature DB >> 35694007

Double Suicide Due to the Ingestion of Levamisole-Adulterated Cocaine: Case Report and Review of the Literature.

Serenella Serinelli, Luigi Bonaccorso, Carmelo Furnari, Lorenzo Gitto.   

Abstract

Suicide is a major public health issue and the risk of attempting and committing suicide increases with age. We present the case of an elderly couple who decided to commit suicide together by self-poisoning using levamisole-adulterated cocaine. The choice of committing a double suicide, the method selected (self-poisoning), the drug self-administered (cocaine), and the route of administration (ingestion) are events rarely encountered in the forensic pathology practice, especially not in combination. In this article, we will review the literature regarding the frequency and features of these methods of suicide. An overview of the effects and mechanism of action of levamisole is also provided, highlighting the importance of including this substance and its metabolites in the routine toxicological analyses for cocaine deaths.
© The Author(s) 2022.

Entities:  

Keywords:  Aminorex; Cocaine; Double suicide; Elderly; Forensic pathology; Levamisole; Suicide

Year:  2021        PMID: 35694007      PMCID: PMC9179001          DOI: 10.1177/19253621211065334

Source DB:  PubMed          Journal:  Acad Forensic Pathol        ISSN: 1925-3621


  59 in total

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Journal:  Crisis       Date:  2000

Review 2.  Adulterants in illicit drugs: a review of empirical evidence.

Authors:  Claire Cole; Lisa Jones; Jim McVeigh; Andrew Kicman; Qutub Syed; Mark Bellis
Journal:  Drug Test Anal       Date:  2010-12-29       Impact factor: 3.345

3.  Levamisole enhances the rewarding and locomotor-activating effects of cocaine in rats.

Authors:  Christopher S Tallarida; Ronald J Tallarida; Scott M Rawls
Journal:  Drug Alcohol Depend       Date:  2015-02-07       Impact factor: 4.492

4.  Levamisole-adulterated cocaine: Two fatal case reports and evaluation of possible cocaine toxicity potentiation.

Authors:  Francesca Indorato; Guido Romano; Nunziata Barbera
Journal:  Forensic Sci Int       Date:  2016-01-14       Impact factor: 2.395

5.  Confronting death from drug self-intoxication (DDSI): prevention through a better definition.

Authors:  Ian R H Rockett; Gordon S Smith; Eric D Caine; Nestor D Kapusta; Randy L Hanzlick; G Luke Larkin; Charles P E Naylor; Kurt B Nolte; Ted R Miller; Sandra L Putnam; Diego De Leo; John Kleinig; Steven Stack; Knox H Todd; David W Fraser
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6.  The relationship between antidepressant medication use and rate of suicide.

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Journal:  Arch Gen Psychiatry       Date:  2005-02

7.  Nine suicide pacts. A clinical study of a consecutive series 1974-93.

Authors:  M Brown; E King; B Barraclough
Journal:  Br J Psychiatry       Date:  1995-10       Impact factor: 9.319

8.  Crime and punishment--the suicide pact.

Authors:  M Rosenbaum
Journal:  Arch Gen Psychiatry       Date:  1983-09

9.  A descriptive study of an outbreak of clenbuterol-containing heroin.

Authors:  Robert S Hoffman; Barbara M Kirrane; Steven M Marcus
Journal:  Ann Emerg Med       Date:  2008-05-23       Impact factor: 5.721

10.  Plasma and Urine Levamisole in Clinical Samples Containing Benzoylecgonine: Absence of Aminorex.

Authors:  S A Handley; S L Belsey; L Couchman; R J Flanagan
Journal:  J Anal Toxicol       Date:  2019-05-01       Impact factor: 3.367

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