Literature DB >> 3569394

Changes in catecholamine levels in discrete regions of rat brain during aging.

I F Roubein, L J Embree, D W Jackson.   

Abstract

The effect of aging on the levels of dopamine (DA) in striatum and noradrenaline (NA) in cerebral cortex, cerebellum, hypothalamus, midbrain and pons-medulla from young adult and five groups of aging rats was evaluated. Determinations of the levels of these amines were conducted. Age-related changes which commenced at 12 months were observed in specific brain regions. The endogenous content of NA decreased significantly in hypothalamus, midbrain, and pons-medulla when compared with the same regions from young adult animals. These results show that central noradrenergic system is markedly vulnerable to the aging process in rats.

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Year:  1986        PMID： 3569394     DOI： 10.1080/03610738608258567

Source DB:  PubMed          Journal:  Exp Aging Res        ISSN： 0361-073X            Impact factor:   1.645


  3 in total

1.  Altered in vivo catecholamine release in the hypothalamic paraventricular nucleus of the aged rat.

Authors:  J A Hastings; J M Pavia; M J Morris
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-01       Impact factor: 3.000

2.  Effect of age and monosodium-L-glutamate (MSG) treatment on neurotransmitter content in brain regions from male Fischer-344 rats.

Authors:  D R Wallace; R Dawson
Journal:  Neurochem Res       Date:  1990-09       Impact factor: 3.996

3.  Age-dependent changes in 24-hour rhythms of catecholamine content and turnover in hypothalamus, corpus striatum and pituitary gland of rats injected with Freund's adjuvant.

Authors:  P Cano; D P Cardinali; F Chacon; P O Castrillón; C A Reyes Toso; A I Esquifino
Journal:  BMC Physiol       Date:  2001-11-28
  3 in total

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