Literature DB >> 35693069

Loss of function mutations in CDKN1A are permissive for APOBEC3-induced mutagenesis in urothelial carcinoma.

Weisi Liu1, Bishoy M Faltas1,2,3,4.   

Abstract

Mutagenic mechanisms that shape the genomic landscape and dysfunction of DNA repair converge to promote bladder tumorigenesis. A recent study by Arnoff and El-Deiry highlights the unique interactions between CDKN1A loss of function mutations, which play a key role in cell cycle regulation, modulating DNA repair, and inducing cell apoptosis and senescence, and APOBEC3-induced mutagenesis, the predominant contributor of mutations in urothelial carcinoma. AJCR
Copyright © 2022.

Entities:  

Keywords:  APOBEC3; CDKN1A; mutagenesis; urothelial carcinoma

Year:  2022        PMID： 35693069      PMCID： PMC9185619     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   5.942


  15 in total

1.  WAF1, a potential mediator of p53 tumor suppression.

Authors:  W S el-Deiry; T Tokino; V E Velculescu; D B Levy; R Parsons; J M Trent; D Lin; W E Mercer; K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

2.  APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo.

Authors:  Jun Fan; Guangyong Ma; Kisato Nosaka; Junko Tanabe; Yorifumi Satou; Atsushi Koito; Simon Wain-Hobson; Jean-Pierre Vartanian; Masao Matsuoka
Journal:  J Virol       Date:  2010-05-12       Impact factor: 5.103

3.  WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

Authors:  W S el-Deiry; J W Harper; P M O'Connor; V E Velculescu; C E Canman; J Jackman; J A Pietenpol; M Burrell; D E Hill; Y Wang
Journal:  Cancer Res       Date:  1994-03-01       Impact factor: 12.701

4.  The repertoire of mutational signatures in human cancer.

Authors:  Ludmil B Alexandrov; Jaegil Kim; Gad Getz; Steven G Rozen; Michael R Stratton; Nicholas J Haradhvala; Mi Ni Huang; Alvin Wei Tian Ng; Yang Wu; Arnoud Boot; Kyle R Covington; Dmitry A Gordenin; Erik N Bergstrom; S M Ashiqul Islam; Nuria Lopez-Bigas; Leszek J Klimczak; John R McPherson; Sandro Morganella; Radhakrishnan Sabarinathan; David A Wheeler; Ville Mustonen
Journal:  Nature       Date:  2020-02-05       Impact factor: 49.962

5.  Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.

Authors:  Isidro Cortés-Ciriano; Jake June-Koo Lee; Ruibin Xi; Dhawal Jain; Youngsook L Jung; Lixing Yang; Dmitry Gordenin; Leszek J Klimczak; Cheng-Zhong Zhang; David S Pellman; Peter J Park
Journal:  Nat Genet       Date:  2020-02-05       Impact factor: 38.330

6.  APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.

Authors:  John Maciejowski; Aikaterini Chatzipli; Alexandra Dananberg; Kevan Chu; Eleonore Toufektchan; Leszek J Klimczak; Dmitry A Gordenin; Peter J Campbell; Titia de Lange
Journal:  Nat Genet       Date:  2020-07-27       Impact factor: 38.330

7.  Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Authors:  Peter C Fong; David S Boss; Timothy A Yap; Andrew Tutt; Peijun Wu; Marja Mergui-Roelvink; Peter Mortimer; Helen Swaisland; Alan Lau; Mark J O'Connor; Alan Ashworth; James Carmichael; Stan B Kaye; Jan H M Schellens; Johann S de Bono
Journal:  N Engl J Med       Date:  2009-06-24       Impact factor: 91.245

8.  Mutational processes molding the genomes of 21 breast cancers.

Authors:  Serena Nik-Zainal; Ludmil B Alexandrov; David C Wedge; Peter Van Loo; Christopher D Greenman; Keiran Raine; David Jones; Jonathan Hinton; John Marshall; Lucy A Stebbings; Andrew Menzies; Sancha Martin; Kenric Leung; Lina Chen; Catherine Leroy; Manasa Ramakrishna; Richard Rance; King Wai Lau; Laura J Mudie; Ignacio Varela; David J McBride; Graham R Bignell; Susanna L Cooke; Adam Shlien; John Gamble; Ian Whitmore; Mark Maddison; Patrick S Tarpey; Helen R Davies; Elli Papaemmanuil; Philip J Stephens; Stuart McLaren; Adam P Butler; Jon W Teague; Göran Jönsson; Judy E Garber; Daniel Silver; Penelope Miron; Aquila Fatima; Sandrine Boyault; Anita Langerød; Andrew Tutt; John W M Martens; Samuel A J R Aparicio; Åke Borg; Anne Vincent Salomon; Gilles Thomas; Anne-Lise Børresen-Dale; Andrea L Richardson; Michael S Neuberger; P Andrew Futreal; Peter J Campbell; Michael R Stratton
Journal:  Cell       Date:  2012-05-17       Impact factor: 41.582

9.  p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.

Authors:  Manikandan Periyasamy; Anup K Singh; Carolina Gemma; Christian Kranjec; Raed Farzan; Damien A Leach; Naveenan Navaratnam; Hajnalka L Pálinkás; Beata G Vértessy; Tim R Fenton; John Doorbar; Frances Fuller-Pace; David W Meek; R Charles Coombes; Laki Buluwela; Simak Ali
Journal:  Nucleic Acids Res       Date:  2017-11-02       Impact factor: 16.971
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