Literature DB >> 3569278

Identical mRNA for preproglucagon in pancreas and gut.

U Novak, A Wilks, G Buell, S McEwen.   

Abstract

The structure of the human glucagon gene and the sequence around the putative promoter region and transcriptional start site are shown. Cloning and sequencing of the cDNAs, coding for preproglucagon from human pancreas and colon, as well as primer extension analysis of RNA from pancreas, ileum and colon point to an identical transcriptional start site in all tissues, about 3 X 10(3) base pairs upstream from the first coding exon as defined by Bell et al.

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Year:  1987        PMID： 3569278     DOI： 10.1111/j.1432-1033.1987.tb11162.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  25 in total

1.  The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties.

Authors:  D M Irwin; M Satkunarajah; Y Wen; P L Brubaker; R A Pederson; M B Wheeler
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

Review 2.  Type 2 diabetes mellitus: a possible surgically reversible intestinal dysfunction.

Authors:  Priscila C Sala; Raquel S Torrinhas; Steven B Heymsfield; Dan L Waitzberg
Journal:  Obes Surg       Date:  2012-01       Impact factor: 4.129

3.  Assessing self-renewal and differentiation in human embryonic stem cell lines.

Authors:  Jingli Cai; Jia Chen; Ying Liu; Takumi Miura; Yongquan Luo; Jeanne F Loring; William J Freed; Mahendra S Rao; Xianmin Zeng
Journal:  Stem Cells       Date:  2005-11-17       Impact factor: 6.277

4.  Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

Authors:  D J Drucker; P L Brubaker
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

Review 5.  Proglucagon-derived peptides: nomenclature, biosynthetic relationships and physiological roles.

Authors:  J M Conlon
Journal:  Diabetologia       Date:  1988-08       Impact factor: 10.122

6.  GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans.

Authors:  B T Schjoldager; P E Mortensen; J Christiansen; C Orskov; J J Holst
Journal:  Dig Dis Sci       Date:  1989-05       Impact factor: 3.199

Review 7.  The role of incretins in glucose homeostasis and diabetes treatment.

Authors:  Wook Kim; Josephine M Egan
Journal:  Pharmacol Rev       Date:  2008-12-12       Impact factor: 25.468

8.  Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin.

Authors:  T Tolessa; M Gutniak; J J Holst; S Efendic; P M Hellström
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

9.  Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.

Authors:  A Wettergren; B Schjoldager; P E Mortensen; J Myhre; J Christiansen; J J Holst
Journal:  Dig Dis Sci       Date:  1993-04       Impact factor: 3.199

Review 10.  Glucagon-like peptide-1, a new hormone of the entero-insular axis.

Authors:  C Orskov
Journal:  Diabetologia       Date:  1992-08       Impact factor: 10.122
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