| Literature DB >> 35683631 |
Sung-Yen Lin1,2,3,4, Cheng-Jung Ho1,3,4, Wen-Chih Liu1,4, Jr-Kai Chen5, Hung-Pin Tu6, Tien-Ching Lee2,3,4,7, Je-Ken Chang1,2,3,4, Chung-Hwan Chen2,3,4,7,8,9,10,11, Cheng-Chang Lu1,2,3,4,12.
Abstract
Anatomical reduction is the fundamental principle of hip function restoration after posterior acetabular wall fractures (PWFs). Some patients exhibit poor outcomes despite anatomical reduction, and the prognostic factors leading to poor outcomes remain elusive. This study aimed to investigate the clinical and radiographic outcomes in patients with PWFs who had undergone anatomical reduction and internal fixation and to identify the predictors that impair clinical and radiologic outcomes. The clinical records of 60 patients with elementary PWFs who had undergone anatomical reduction and internal fixation between January 2005 and July 2015 were reviewed retrospectively. The Harris hip score (HHS) and modified Merle d'Aubigné clinical hip scores (MMAS) were used to evaluate the clinical outcome. Preoperative and final follow-up radiographs were cross checked to identify poor radiographic outcomes that included the presence of advanced osteoarthritis and osteonecrosis, as well as the need for conversion to total hip arthroplasty. Acetabular dome comminution was assessed from computerized tomography, and the outcomes were further evaluated according to the involvement of fragment comminution. The fracture comminution and age were negatively correlated with functional outcomes (correlation coefficients were -0.41 and -0.39 in HHS and MMAS, respectively) and were significantly related to the severity of osteoarthritis and osteonecrosis as well as the need for total hip arthroplasty. Regarding the radiographic factors, significantly worse post-operative HHS and MMAS were found in the fracture comminution group. In the subanalysis of the status of fracture comminution, patients with fragment comminution involving the acetabular dome had significantly lower functional scores than those with other fracture patterns. In conclusion, age, fracture comminution, and dome comminution were the prognostic indicators of advanced osteoarthritis and poor functional scores after the anatomical reduction and internal fixation of PWFs. We emphasized the relevance of acetabular dome comminution as an important contributing factor to clinical and radiographic outcomes.Entities:
Keywords: acetabular dome; anatomical reduction and internal fixation; fracture comminution; osteoarthritis; osteonecrosis; posterior wall acetabular fracture
Year: 2022 PMID: 35683631 PMCID: PMC9180942 DOI: 10.3390/jcm11113244
Source DB: PubMed Journal: J Clin Med ISSN: 2077-0383 Impact factor: 4.964
Figure 1A 55-year-old male patient with injury to the right hip in a traffic accident. Preoperative radiography and CT scan reveal comminuted posterior right acetabular wall fracture associated with dome comminution (a,b). Open reduction and internal fixation with additional three spring plates have been performed to stabilize the comminuted fragments. Postoperative radiography shows good reduction of the acetabular joint surface (c,d).
The patients’ preoperative and postoperative clinical and radiographic data.
| Total Patients | |
|---|---|
| N | 60 |
| Age, years | |
| Mean (SD) | 39.1(17.3) |
| Sex, | |
| Female | 16 (26.7) |
| Male | 44 (73.3) |
| Preoperative CT evaluation, | |
| Fracture comminution | 37 (61.7) |
| Dome comminution | 19 (31.7) |
| Dislocation | 25 (41.7) |
| Marginal impaction | 11 (18.3) |
| Femoral head injury | 13 (21.7) |
| Clinical function outcomes | |
| HSS | |
| Mean (SD) | 85.5 (20.1) |
| MMAS | |
| Mean (SD) | 15.3 (2.5) |
| Radiographic outcomes, | |
| OA | |
| Early stage (stage 0–2) | 49 (81.7) |
| Advanced stage (stage 3–4) | 11 (18.3) |
| ON | |
| Early stage (stage 0–2) | 55 (91.7) |
| Advanced stage (stage 3–4) | 5 (8.3) |
| Convert to THA | |
| No | 54 (90.0) |
| Yes | 6 (10.0) |
Values are percentage (%), standard deviation (SD), interquartile range (IQR). HSS, Harris hip score; MMAS, modified Merled’Aubigné-Postel score; OA, osteoarthritis; ON: osteonecrosis; THA: total hip arthroplasty.
Figure 2The correlations between patient age and postoperative functional scores. The Spearman rank correlations are −0.41 in (a) HHS (p < 0.0012) and −0.39 in (b) MMAS (p = 0.0019), indicating a negative moderate correlation between patient age and functional scores.
The prognostic factors related to clinical outcomes (HHS and MMAS).
| HSS |
| MMAS |
| |
|---|---|---|---|---|
| Age, Spearman’s rho | −0.41 | 0.0012 * | −0.39 | 0.0019 * |
| Sex, Median (IQR) | ||||
| Female | 92.5 (89.0–96.0) | 16.0 (15.0–17.0) | ||
| Male | 93.5 (85.0–96.0) | 0.9665 | 16.0 (15.0–17.0) | 0.7110 |
| Preoperative radiographic factors, Median (IQR) | ||||
| Fracture comminution | ||||
| No | 96.0 (95.0–100.0) | 17.0 (16.0–18.0) | ||
| Yes | 90.0 (78.0–93.0) | <0.0001 * | 15.0 (13.0–16.0) | <0.0001 * |
| Dome comminution | ||||
| No | 95.0 (93.0–96.0) | 16.0 (16.0–17.0) | ||
| Yes | 80.0 (42.0–91.0) | <0.0001 * | 13.0 (10.0–16.0) | <0.0001 * |
| Dislocation | ||||
| No | 95.0 (88.0–96.0) | 16.0 (16.0–17.0) | ||
| Yes | 92.0 (80.0–94.0) | 0.0765 | 16.0 (14.0–16.0) | 0.0717 |
| Marginal impaction | ||||
| No | 94.0 (86.0–96.0) | 16.0 (15.0–17.0) | ||
| Yes | 91.0 (83.0–93.0) | 0.1267 | 15.0 (15.0–16.0) | 0.1805 |
| Femoral head injury | ||||
| No | 94.0 (88.0–96.0) | 16.0 (15.0–17.0) | ||
| Yes | 92.0 (85.0–95.0) | 0.3166 | 16.0 (15.0–16.0) | 0.2553 |
HSS, Harris hip score; MMAS, modified Merled’Aubigné-Postel score. * p < 0.05.
The prognostic factors related to radiographic outcomes (OA, ON and THA).
| OA | ON | THA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Early Stage | Advanced Stage |
| Early Stage | Advanced Stage |
| No | Yes |
| |
|
| 49 | 11 | 55 | 5 | 54 | 6 | |||
| Age, | |||||||||
| Mean (SD) | 36.4 (17.3) | 51.1 (12.1) | 0.0100 * | 37.8 (17.4) | 53.8 (7.3) | 0.0468 * | 37.6 (17.5) | 53 (6.4) | 0.0374 * |
| Median (IQR) | 31.0 (22.0–43.0) | 51.0 (46.0–60.0) | 0.0057 * | 33.0 (24.0–51.0) | 57.0 (46.0–59.0) | 0.0302 * | 33.0 (24.0–51.0) | 53.5 (46.0–59.0) | 0.0226 * |
| Sex female, | 15 (30.6) | 1 (9.1) | 0.2586 | 16 (29.1) | 0 (0.0) | 0.3113 | 15 (27.8) | 1 (16.7) | 1.0000 |
| Fracture comminution | 26 (53.1) | 11 (100.0) | 0.0042 * | 32 (58.2) | 5 (100.0) | 0.1460 | 31 (57.4) | 6 (100.0) | 0.0733 |
| Dome comminution | 9 (18.4) | 10(90.9) | <0.0001 * | 15 (27.3) | 4 (80.0) | 0.0312 * | 13 (24.1) | 6 (100.0) | 0.0005 * |
| Dislocation | 18 (36.7) | 7 (63.6) | 0.1744 | 22 (40.0) | 3 (60.0) | 0.6405 | 21 (38.9) | 4 (66.7) | 0.2234 |
| Marginal impaction | 9 (18.4) | 2 (18.2) | 1.0000 | 10 (18.2) | 1 (20.0) | 1.0000 | 10 (18.5) | 1 (16.7) | 1.0000 |
| Femoral head injury | 10 (20.4) | 3 (27.3) | 0.6899 | 12 (21.8) | 1 (20.0) | 1.0000 | 12 (22.2) | 1 (16.7) | 1.0000 |
OA, osteoarthritis; ON: osteonecrosis; THA: total hip arthroplasty. * p < 0.05.
The effects of different status of comminution on clinical and radiographic outcomes in patients with PWF.
| Group 1 | Group 2 | Group 3 | ||
|---|---|---|---|---|
| No Fragment Comminution | Fragment Comminution but Not Dome Comminution | Acetabular Dome Comminution |
| |
| Total patients, | 23 | 18 | 19 | |
| HSS, LS-mean (SE) ** | 93.87 (3.11) | 92.64 (3.50) | 68.45 (3.33) | <0.0001 * |
| MMAS, LS-mean (SE) ** | 16.62 (0.35) | 15.98 (0.39) | 13.06 (0.38) | <0.0001 * |
| OA, | ||||
| Early stage | 23 (100.0) | 17 (94.4) | 9 (47.4) | <0.0001 * |
| Advanced stage | 0 (0.0) | 1 (5.6) | 10 (52.6) | |
| ON, | ||||
| Early stage | 23(100.0) | 17 (94.4) | 15 (78.9) | 0.0333 * |
| Advanced stage | 0 (0.0) | 1 (5.6) | 4 (21.1) | |
| THA, | ||||
| No | 23(100.0) | 18 (100.0) | 13 (68.4) | 0.0009 * |
| Yes | 0 (0.0) | 0 (0.0) | 6 (31.6) |
SE: standard error; LS-mean: Least-squares means. Group 1: no fragment comminution; Group 2: fragment comminution but not dome comminution; Group 3: acetabular dome comminution. HSS, Harris hip score; MMAS, modified Merled’Aubigné-Postel score; OA, osteoarthritis; ON: osteonecrosis; THA: total hip arthroplasty; * p < 0.05, ** Data set was calculated after the adjustment of age using a generalized linear regression model. † p values were calculated with the use of a Fisher’s exact test to compare fracture comminution with clinical and radiographic outcomes. ‡ Adjusted odds ratio (OR) with 95% confidence interval (CI) was estimated after adjustment for age using multinomial logistic regression.
Post hoc comparisons for the effects of different status of comminution on clinical and radiographic outcomes in patients with PWF.
| Post hoc Analysis | Group 1 vs. Group 2 | Group 1 vs. Group 3 | Group 2 vs. Group 3 | |||
|---|---|---|---|---|---|---|
| Difference |
| Difference |
| Difference |
| |
| Total patients, | ||||||
| HSS, LS-mean (SE) ** | −1.24 (4.80) | 1.0000 | −25.43 (4.58) | <0.0001* | −24.19 (4.81) | <0.0001 * |
| MMAS, LS-mean (SE) ** | −0.64 (0.54) | 0.4769 | −3.56 (0.52) | <0.0001* | −2.92 (0.54) | <0.0001 * |
| OA, | ||||||
| Early stage | 1.00 | 1.00 | 1.00 | |||
| Advanced stage | 4.03 (0.15–104.93) | 0.4390 | 51.95 (2.76–978.12) | <0.0001* | 58.96 (3.90–891.8) | 0.0033 * |
| ON, | ||||||
| Early stage | 1.00 | 1.00 | 1.00 | |||
| Advanced stage | 4.03 (0.15–104.93) | 0.4390 | 13.65 (0.69–271.70) | 0.0346* | 6.43 (0.60–69.33) | 0.1250 |
| THA, | ||||||
| No | 1.00 | 1.00 | 1.00 | |||
| Yes | - | - | - | - | 22.63 (1.18–433.78) | 0.0052 * |
SE: standard error; LS-mean: Least-squares means. Group 1: no fragment comminution; Group 2: fragment comminution but not dome comminution; Group 3: acetabular dome comminution. HSS, Harris hip score; MMAS, modified Merled’Aubigné-Postel score; OA, osteoarthritis; ON: osteonecrosis; THA: total hip arthroplasty; * p < 0.05, ** Data set was calculated after the adjustment of age using a generalized linear regression model. † p values were calculated with the use of a Fisher’s exact test to compare fracture comminution with clinical and radiographic outcomes. ‡ Adjusted odds ratio (OR) with 95% confidence interval (CI) was estimated after adjustment for age using multinomial logistic regression.