| Literature DB >> 35678998 |
Qing Zhou1,2, Ying Liu1,2, Ranran Feng1,2, Wenling Zhang3,4.
Abstract
Nucleobindin2 (NUCB2) is a member of nucleobindin family which was first found in the nucleus of the hypothalamus, and had a relationship in diet and energy homeostasis. Its location in normal tissues such as stomach and islet further confirms that it plays a vital role in the regulation of physiological functions of the body. Besides, NUCB2 participates in tumorigenesis through activating various signal-pathways, more and more studies indicate that NUCB2 might impact tumor progression by promoting or inhibiting proliferation, apoptosis, autophagy, metastasis, and invasion of tumor cells. In this review, we comprehensively stated NUCB2's expression and functions, and introduced the role of NUCB2 in physiology and pathology and its mechanism. What is more, pointed out the potential direction of future research.Entities:
Keywords: Appetite regulation; Energy homeostasis; NUCB2; Tumorigenesis
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Year: 2022 PMID： 35678998 DOI： 10.1007/s13105-022-00895-4
Source DB: PubMed Journal: J Physiol Biochem ISSN： 1138-7548 Impact factor: 5.080