Autoimmune neutropenia and Hodgkin's disease.

Isolated neutropenia developed in a patient who had been treated 4 years previously for Stage IIA nodular sclerosing Hodgkin's disease with mantle radiation therapy. Bone marrow revealed myeloid hyperplasia with a virtual absence of bands and polymorphonuclear leukocytes. The serum was positive for antigranulocyte antibodies. There was no evidence of recurrent Hodgkin's disease. Guidelines for the evaluation and treatment of immune neutropenia in Hodgkin's disease are suggested.