Vikram K Mahajan1, Narvir S Chauhan2, Baldev S Rana3, Karaninder S Mehta1, Sheenam Hooda1, Pushpinder S Chauhan1, Amisha Kukreja1. 1. Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Government Medical College, Kangra (Tanda), 176001 Himachal Pradesh, India. 2. Department of Radio Diagnosis, Dr. Rajendra Prasad Government Medical College, Kangra (Tanda), 176001 Himachal Pradesh, India. 3. Department of Gastroenterology & Hepatology, Dr. Rajendra Prasad Government Medical College, Kangra (Tanda), 176001 Himachal Pradesh, India.
Abstract
Background: Psoriasis is a chronic dermatosis with potential to cause systemic disease by triggering dysmetabolism, such as metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). We studied the relationship and associations between NAFLD and clinical features, including age, gender, disease duration, and severity of psoriasis in our patients. Methods: This cross-sectional study comprised 61 (m:f, 43:19) patients without pre-existing comorbidities and matched 24 (m:f, 16:8) healthy controls aged between 20 and 68 years. Disease severity was graded as mild, moderate, and severe by psoriasis area and severity index score and body surface area (BSA) involvement. The grades of fatty liver and liver fibrosis were assessed using liver ultrasonography (USG) and transitional vibration-controlled elastography (Fibroscan). Results: Overall, 67.2% of patients were aged >40 years, and the duration of disease was <5years in 60.7% of patients. Mild and moderate to severe psoriasis occurred in 78.7% and 21.3% of patients, respectively. BSA was >10% in 57.5% patients. The proportion of NAFLD was 27.9% and 32.8% by USG and Fibroscan compared with 20.8% in controls. Statistically, there was no significant difference or association between the prevalence of NAFLD among patients and controls, and gender, age (mean ± standard deviation, 47.5 ± 13.8 vs. 45.2 ± 15.7), duration, severity of psoriasis, and arthritis between psoriatic patients with and without NAFLD. Conclusion: This was a pilot study because of the numerosity of sample and highlights trends for possible link between psoriasis and NAFLD, but the results need cautious interpretation and clinical application. Whether NAFLD can be attributed to overall systemic inflammatory process of psoriasis or it occurs as an epiphenomenon of concurrent metabolic syndrome needs elucidation with well-designed studies. Cross-sectional study design, small number of patients, and controls remain major limitations. The study did not compare its findings with liver biopsy.
Background: Psoriasis is a chronic dermatosis with potential to cause systemic disease by triggering dysmetabolism, such as metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). We studied the relationship and associations between NAFLD and clinical features, including age, gender, disease duration, and severity of psoriasis in our patients. Methods: This cross-sectional study comprised 61 (m:f, 43:19) patients without pre-existing comorbidities and matched 24 (m:f, 16:8) healthy controls aged between 20 and 68 years. Disease severity was graded as mild, moderate, and severe by psoriasis area and severity index score and body surface area (BSA) involvement. The grades of fatty liver and liver fibrosis were assessed using liver ultrasonography (USG) and transitional vibration-controlled elastography (Fibroscan). Results: Overall, 67.2% of patients were aged >40 years, and the duration of disease was <5years in 60.7% of patients. Mild and moderate to severe psoriasis occurred in 78.7% and 21.3% of patients, respectively. BSA was >10% in 57.5% patients. The proportion of NAFLD was 27.9% and 32.8% by USG and Fibroscan compared with 20.8% in controls. Statistically, there was no significant difference or association between the prevalence of NAFLD among patients and controls, and gender, age (mean ± standard deviation, 47.5 ± 13.8 vs. 45.2 ± 15.7), duration, severity of psoriasis, and arthritis between psoriatic patients with and without NAFLD. Conclusion: This was a pilot study because of the numerosity of sample and highlights trends for possible link between psoriasis and NAFLD, but the results need cautious interpretation and clinical application. Whether NAFLD can be attributed to overall systemic inflammatory process of psoriasis or it occurs as an epiphenomenon of concurrent metabolic syndrome needs elucidation with well-designed studies. Cross-sectional study design, small number of patients, and controls remain major limitations. The study did not compare its findings with liver biopsy.
Authors: Y Tang; Z Bian; L Zhao; Y Liu; S Liang; Q Wang; X Han; Y Peng; X Chen; L Shen; D Qiu; Z Li; X Ma Journal: Clin Exp Immunol Date: 2011-11 Impact factor: 4.330
Authors: R Candia; A Ruiz; R Torres-Robles; N Chávez-Tapia; N Méndez-Sánchez; M Arrese Journal: J Eur Acad Dermatol Venereol Date: 2014-11-21 Impact factor: 6.166
Authors: Andrea Chiricozzi; Martina Burlando; Giacomo Caldarola; Andrea Conti; Giovanni Damiani; Clara De Simone; Valentina Dini; Piergiorgio Malagoli; Francesca Peccerillo; Concetta Potenza; Emanuele Scala; Nevena Skroza; Anna Balato Journal: Am J Clin Dermatol Date: 2020-06 Impact factor: 7.403
Authors: Giovanni Damiani; Abdulla Watad; Charlie Bridgewood; Paolo Daniele Maria Pigatto; Alessia Pacifico; Piergiorgio Malagoli; Nicola Luigi Bragazzi; Mohammad Adawi Journal: Nutrients Date: 2019-01-27 Impact factor: 5.717
Authors: Rosalynn Rz Conic; Giovanni Damiani; Kory P Schrom; Amy E Ramser; Chunlei Zheng; Rong Xu; Thomas S McCormick; Kevin D Cooper Journal: J Clin Med Date: 2020-01-09 Impact factor: 4.241