Claudia Vetrani1, Luigi Barrea2,3, Ludovica Verde1, Gerardo Sarno4, Annamaria Docimo1, Giulia de Alteriis1, Silvia Savastano1,3, Annamaria Colao1,3,5, Giovanna Muscogiuri6,7,8. 1. Dipartimento di Medicina Clinica e Chirurgia, Unità di Endocrinologia, Diabetologia ed Andrologia, Università Federico II, Napoli, Italy. 2. Dipartimento di Scienze Umanistiche, Università Telematica Pegaso, 80143, Napoli, Italy. 3. Italian Centre for the Care and Well-Being of Patients with Obesity (C.I.B.O), University of Naples "Federico II", Naples, Italy. 4. "San Giovanni di Dio e Ruggi D'Aragona" University Hospital, Scuola Medica Salernitana, Salerno, Italy. 5. UNESCO Chair "Education for Health and Sustainable Development", University of Naples "Federico II", Naples, Italy. 6. Dipartimento di Medicina Clinica e Chirurgia, Unità di Endocrinologia, Diabetologia ed Andrologia, Università Federico II, Napoli, Italy. giovanna.muscogiuri@gmail.com. 7. Italian Centre for the Care and Well-Being of Patients with Obesity (C.I.B.O), University of Naples "Federico II", Naples, Italy. giovanna.muscogiuri@gmail.com. 8. UNESCO Chair "Education for Health and Sustainable Development", University of Naples "Federico II", Naples, Italy. giovanna.muscogiuri@gmail.com.
Abstract
BACKGROUND/ OBJECTIVES: Chronotype, i.e., the individual attitude to carry out the daily activities at a certain time of the day, has been reported to play a role in metabolic diseases. Thus, the aim of our study was to investigate the association of non-alcoholic fatty liver disease (NAFLD) with chronotype categories in individuals with obesity. SUBJECTS/ METHODS: In this cross-sectional study, participants underwent to anthropometric, biochemical, and the Visceral Adiposity Index (VAI) assessment. Chronotype categories were assessed by the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ). The following indirect indices of NAFLD were calculated: Liver Fat Equation (LFE), Hepatic Steatosis Index (HSI) and Index of Non-alcoholic steatohepatitis (ION). RESULTS: The study population consisted of 87 participants (40.3 ± 12.3 years; BMI 45.6 ± 6.3 kg/m2; 64F/23M). According to the chronotype score, 31.0% were morning (MC), 36.8% were intermediate (IC), and 32.2% evening chronotype (EC). Individuals with IC were significantly younger than those with MC and EC (p = 0.002 and p = 0.047, respectively). EC presented significantly higher BMI (p < 0.001), waist circumference (p = 0.007), and hip circumference (p = 0.001) than MC. Moreover, EC had higher BMI (p < 0.001) and waist circumference (p = 0.011) than IC. All participants presented NAFLD (HSI ≥ 36 and LFE ≥ 5). Nevertheless, only individuals with EC were above the threshold of non-alcoholic steatohepatitis evaluated as ION index (ION ≥ 50). Individuals with EC presented significantly higher VAI (p = 0.036), LFE (p = 0.034), HSI (p < 0.001) and ION (p = 0.014) than MC, also after the adjustment for age, gender, and BMI. CONCLUSION: EC is associated with more severe NAFLD independently of age, gender, and BMI than MC and IC in individuals with obesity.
BACKGROUND/ OBJECTIVES: Chronotype, i.e., the individual attitude to carry out the daily activities at a certain time of the day, has been reported to play a role in metabolic diseases. Thus, the aim of our study was to investigate the association of non-alcoholic fatty liver disease (NAFLD) with chronotype categories in individuals with obesity. SUBJECTS/ METHODS: In this cross-sectional study, participants underwent to anthropometric, biochemical, and the Visceral Adiposity Index (VAI) assessment. Chronotype categories were assessed by the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ). The following indirect indices of NAFLD were calculated: Liver Fat Equation (LFE), Hepatic Steatosis Index (HSI) and Index of Non-alcoholic steatohepatitis (ION). RESULTS: The study population consisted of 87 participants (40.3 ± 12.3 years; BMI 45.6 ± 6.3 kg/m2; 64F/23M). According to the chronotype score, 31.0% were morning (MC), 36.8% were intermediate (IC), and 32.2% evening chronotype (EC). Individuals with IC were significantly younger than those with MC and EC (p = 0.002 and p = 0.047, respectively). EC presented significantly higher BMI (p < 0.001), waist circumference (p = 0.007), and hip circumference (p = 0.001) than MC. Moreover, EC had higher BMI (p < 0.001) and waist circumference (p = 0.011) than IC. All participants presented NAFLD (HSI ≥ 36 and LFE ≥ 5). Nevertheless, only individuals with EC were above the threshold of non-alcoholic steatohepatitis evaluated as ION index (ION ≥ 50). Individuals with EC presented significantly higher VAI (p = 0.036), LFE (p = 0.034), HSI (p < 0.001) and ION (p = 0.014) than MC, also after the adjustment for age, gender, and BMI. CONCLUSION: EC is associated with more severe NAFLD independently of age, gender, and BMI than MC and IC in individuals with obesity.
Authors: Patricia M Wong; Brant P Hasler; Thomas W Kamarck; Matthew F Muldoon; Stephen B Manuck Journal: J Clin Endocrinol Metab Date: 2015-11-18 Impact factor: 5.958
Authors: Frank A J L Scheer; Michael F Hilton; Christos S Mantzoros; Steven A Shea Journal: Proc Natl Acad Sci U S A Date: 2009-03-02 Impact factor: 11.205
Authors: Shivakumar Chitturi; Shehan Abeygunasekera; Geoffrey C Farrell; Jane Holmes-Walker; Jason M Hui; Caroline Fung; Rooshdiya Karim; Rita Lin; Dev Samarasinghe; Christopher Liddle; Martin Weltman; Jacob George Journal: Hepatology Date: 2002-02 Impact factor: 17.425
Authors: Fred W Turek; Corinne Joshu; Akira Kohsaka; Emily Lin; Ganka Ivanova; Erin McDearmon; Aaron Laposky; Sue Losee-Olson; Amy Easton; Dalan R Jensen; Robert H Eckel; Joseph S Takahashi; Joseph Bass Journal: Science Date: 2005-04-21 Impact factor: 47.728
Authors: Dirk Jan Stenvers; Frank A J L Scheer; Patrick Schrauwen; Susanne E la Fleur; Andries Kalsbeek Journal: Nat Rev Endocrinol Date: 2019-02 Impact factor: 43.330