Literature DB >> 35673457

Genomic medicine on the frontier of precision medicine.

Mandana Hasanzad1,2, Negar Sarhangi2, Anoosh Naghavi3, Ehsan Ghavimehr1, Fatemeh Khatami4, Sima Ehsani Chimeh5, Bagher Larijani6, Hamid Reza Aghaei Meybodi2.   

Abstract

Genomic medicine has created a great deal of hope since the completion of the Human Genome Project (HGP). Genomic medicine promises disease prevention and early diagnosis in the context of precision medicine. Precision medicine as a scientific discipline has introduced as an evolution in medicine. The rapid growth of high-development technologies permits the assessment of biological systems. Study of the integrated profiles of omics, such as genome, transcriptome, proteome and other omics information lead to significant advances in personalized and precision medicine. In the context of precision medicine, pharmacogenomics can play an important role in order to discriminate responders and non-responders to medications and avoiding toxicity and achieving the optimum dose. So precision medicine in accordance with genomic medicine will transform medicine from conventional evidence-based medicine in the diagnosis and treatment towards precision based-medicine. In this review, we have summarized the related issues for genomic medicine and precision medicine. © Springer Nature Switzerland AG 2021.

Entities:  

Keywords:  GWAS; Genomic medicine; Omics; Pharmacogenomics; Precision medicine

Year:  2021        PMID: 35673457      PMCID: PMC9167337          DOI: 10.1007/s40200-021-00880-6

Source DB:  PubMed          Journal:  J Diabetes Metab Disord        ISSN: 2251-6581


  37 in total

1.  Characterization of single-nucleotide polymorphisms in coding regions of human genes.

Authors:  M Cargill; D Altshuler; J Ireland; P Sklar; K Ardlie; N Patil; N Shaw; C R Lane; E P Lim; N Kalyanaraman; J Nemesh; L Ziaugra; L Friedland; A Rolfe; J Warrington; R Lipshutz; G Q Daley; E S Lander
Journal:  Nat Genet       Date:  1999-07       Impact factor: 38.330

2.  Efficient selective screening of haplotype tag SNPs.

Authors:  Xiayi Ke; Lon R Cardon
Journal:  Bioinformatics       Date:  2003-01-22       Impact factor: 6.937

3.  Hippocrates and genomic medicine.

Authors:  Gerasimos P Sykiotis; George D Kalliolias; Athanasios G Papavassiliou
Journal:  Arch Med Res       Date:  2006-01       Impact factor: 2.235

Review 4.  Beyond GWASs: illuminating the dark road from association to function.

Authors:  Stacey L Edwards; Jonathan Beesley; Juliet D French; Alison M Dunning
Journal:  Am J Hum Genet       Date:  2013-11-07       Impact factor: 11.025

Review 5.  The era of genomic medicine.

Authors:  Kay Davies
Journal:  Clin Med (Lond)       Date:  2013-12       Impact factor: 2.659

6.  New goals for the U.S. Human Genome Project: 1998-2003.

Authors:  F S Collins; A Patrinos; E Jordan; A Chakravarti; R Gesteland; L Walters
Journal:  Science       Date:  1998-10-23       Impact factor: 47.728

Review 7.  Electronic health records and polygenic risk scores for predicting disease risk.

Authors:  Ruowang Li; Yong Chen; Marylyn D Ritchie; Jason H Moore
Journal:  Nat Rev Genet       Date:  2020-03-31       Impact factor: 53.242

8.  Identifying multiple causative genes at a single GWAS locus.

Authors:  Michael J Flister; Shirng-Wern Tsaih; Caitlin C O'Meara; Bradley Endres; Matthew J Hoffman; Aron M Geurts; Melinda R Dwinell; Jozef Lazar; Howard J Jacob; Carol Moreno
Journal:  Genome Res       Date:  2013-09-04       Impact factor: 9.043

Review 9.  Multi-omics approaches to disease.

Authors:  Yehudit Hasin; Marcus Seldin; Aldons Lusis
Journal:  Genome Biol       Date:  2017-05-05       Impact factor: 13.583

10.  Genetic architecture of complex traits and disease risk predictors.

Authors:  Soke Yuen Yong; Timothy G Raben; Louis Lello; Stephen D H Hsu
Journal:  Sci Rep       Date:  2020-07-21       Impact factor: 4.379

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