| Literature DB >> 35670654 |
Zahra Shirzadi1, Wai-Ying W Yau1, Stephanie A Schultz1, Aaron P Schultz1, Matthew R Scott1, Maged Goubran2, Parisa Mojiri-Forooshani2, Nelly Joseph-Mathurin3, Kejal Kantarci4, Greg Preboske4, Marieke J H Wermer5, Clifford Jack4, Tammie Benzinger3, Kevin Taddei6, Hamid R Sohrabi7, Reisa A Sperling1, Keith A Johnson1, Randall J Bateman3, Ralph N Martins6, Steven M Greenberg1, Jasmeer P Chhatwal1.
Abstract
Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358-363.Entities:
Mesh：
Year: 2022 PMID： 35670654 PMCID： PMC9391284 DOI： 10.1002/ana.26429
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 11.274