Literature DB >> 3567052

Age-related changes in trimethadione oxidizing capacity.

E Tanaka, A Ishikawa, A Ono, T Okamura, S Misawa.   

Abstract

The metabolism of trimethadione (TMO) following oral administration (4 mg kg-1) has been studied in 11 young male and 11 elderly male patients. The elimination half-life (h) of TMO was 11.8 +/- 1.4 (mean +/- s.e. mean) in the young and 23.5 +/- 2.17 in the elderly (P less than 0.01). Total body clearance (1 h-1 kg-1) was 41.4 +/- 2.8 in the young and 29.0 +/- 2.4 in the elderly (P less than 0.01). The apparent volume of distribution (1 kg-1) was 0.67 +/- 0.03 in the young and 0.65 +/- 0.04 in the elderly. Serum dimethadione (DMO)/TMO ratios at 4 h were 0.65 +/- 0.03 in the young and 0.46 +/- 0.03 in the elderly (P less than 0.01). These results suggest that N-demethylation of TMO is inversely related to age.

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Year:  1987        PMID： 3567052      PMCID： PMC1386237          DOI： 10.1111/j.1365-2125.1987.tb03058.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  10 in total

1.  Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking.

Authors:  R E Vestal; A H Norris; J D Tobin; B H Cohen; N W Shock; R Andres
Journal:  Clin Pharmacol Ther       Date:  1975-10       Impact factor: 6.875

Review 2.  Assessment of the drug metabolism capacity of the liver.

Authors:  B K Park
Journal:  Br J Clin Pharmacol       Date:  1982-11       Impact factor: 4.335

3.  Determination of trimethadione and its metabolite by gas chromatography with flame-thermionic detection and its application to pharmacokinetic studies of the drug in carbon tetrachloride-treated rats.

Authors:  E Tanaka; H Kinoshita; T Yoshida; Y Kuroiwa
Journal:  J Chromatogr       Date:  1983-02-11

4.  Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.

Authors:  D J Greenblatt; M Divoll; D R Abernethy; J S Harmatz; R I Shader
Journal:  J Pharmacol Exp Ther       Date:  1982-01       Impact factor: 4.030

5.  Drugs as indicators of hepatic function.

Authors:  R A Branch
Journal:  Hepatology       Date:  1982 Jan-Feb       Impact factor: 17.425

6.  Effect of age and sex on the N-demethylation rate of 14C-aminopyrine, studied by the breath test.

Authors:  J Pirotte; D El Allaf
Journal:  Digestion       Date:  1983       Impact factor: 3.216

7.  Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity.

Authors:  D J Greenblatt; M Divoll; D R Abernethy; L J Moschitto; R B Smith; R I Shader
Journal:  Br J Clin Pharmacol       Date:  1983-03       Impact factor: 4.335

8.  A method for estimation of hepatic drug-metabolizing capacity: determination of concentration of trimethadione and its metabolite in human serum.

Authors:  S Kobayashi; E Tanaka; K Oguchi; T Yoshida; Y Kuroiwa; H Yasuhara
Journal:  J Pharmacobiodyn       Date:  1984-05

9.  Trimethadione tolerance test for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices.

Authors:  E Tanaka; A Ishikawa; A Ono; T Okamura; S Kobayashi; H Yasuhara; S Misawa
Journal:  J Pharmacobiodyn       Date:  1986-03

10.  Imipramine and desipramine disposition in the elderly.

Authors:  D R Abernethy; D J Greenblatt; R I Shader
Journal:  J Pharmacol Exp Ther       Date:  1985-01       Impact factor: 4.030
  10 in total
  1 in total

1.  Comparison of trimethadione and antipyrine as indicators of oxidative drug metabolizing capacity in man.

Authors:  E Tanaka; K Nakamura
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953
  1 in total

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