Literature DB >> 3567018

The effects of age on carbamazepine pharmacokinetics and adverse effects.

N Hockings, A Pall, J Moody, A V Davidson, D L Davidson.   

Abstract

The pharmacokinetics and effect of single oral doses of carbamazepine (400 mg) were compared in a group of six young volunteers aged between 20 and 25 years, and a second group of five elderly volunteers aged between 66 and 84 years. No age related changes in salivary or plasma pharmacokinetics or in psychomotor function were detected.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3567018      PMCID： PMC1401196          DOI： 10.1111/j.1365-2125.1986.tb02965.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  8 in total

1.  Measurement of carbamazepine and its epoxide metabolite by high-performance liquid chromatography, and a comparison of assay techniques for the analysis of carbamazepine.

Authors:  G W Mihaly; J A Phillips; W J Louis; F J Vajda
Journal:  Clin Chem       Date:  1977-12       Impact factor: 8.327

Review 2.  Psychomotor function and psychoactive drugs.

Authors:  I Hindmarch
Journal:  Br J Clin Pharmacol       Date:  1980-09       Impact factor: 4.335

3.  Distribution and elimination kinetics of carbamazepine in man.

Authors:  M D Rawlins; P Collste; L Bertilsson; L Palmér
Journal:  Eur J Clin Pharmacol       Date:  1975-02-28       Impact factor: 2.953

4.  Salivary concentrations and plasma protein binding of carbamazepine and carbamazepine 10,11-epoxide in epileptic patients.

Authors:  J J MacKichan; P K Duffner; M E Cohen
Journal:  Br J Clin Pharmacol       Date:  1981-07       Impact factor: 4.335

5.  Drug disposition in the elderly: a review of the critical factors.

Authors:  D L Schmucker
Journal:  J Am Geriatr Soc       Date:  1984-02       Impact factor: 5.562

6.  Saliva carbamazepine levels in children before and during multiple dosing.

Authors:  T A Moreland; D A Priestman; G W Rylance
Journal:  Br J Clin Pharmacol       Date:  1982-05       Impact factor: 4.335

7.  Concentrations and kinetics of carbamazepine in whole saliva, parotid saliva, serum ultrafiltrate, and serum.

Authors:  J W Paxton; R A Donald
Journal:  Clin Pharmacol Ther       Date:  1980-11       Impact factor: 6.875

8.  Value of saliva samples in monitoring carbamazepine concentrations in epileptic patients.

Authors:  O Kristensen; H F Larsen
Journal:  Acta Neurol Scand       Date:  1980-06       Impact factor: 3.209
  8 in total
  10 in total

1.  Population pharmacokinetics of carbamazepine in elderly patients.

Authors:  Baralee Punyawudho; Eugene R Ramsay; Richard C Brundage; Flavia M Macias; Joseph F Collins; Angela K Birnbaum
Journal:  Ther Drug Monit       Date:  2012-04       Impact factor: 3.681

Review 2.  Hepatic drug metabolism and aging.

Authors:  C Durnas; C M Loi; B J Cusack
Journal:  Clin Pharmacokinet       Date:  1990-11       Impact factor: 6.447

Review 3.  The effects of fall-risk-increasing drugs on postural control: a literature review.

Authors:  Maartje H de Groot; Jos P C M van Campen; Marije A Moek; Linda R Tulner; Jos H Beijnen; Claudine J C Lamoth
Journal:  Drugs Aging       Date:  2013-11       Impact factor: 3.923

Review 4.  Treatment recommendations for anticonvulsant drug therapy in the older patient.

Authors:  P D Swanson
Journal:  Drugs Aging       Date:  1992 Mar-Apr       Impact factor: 3.923

Review 5.  Anticonvulsant therapy in aged patients. Clinical pharmacokinetic considerations.

Authors:  I Bernus; R G Dickinson; W D Hooper; M J Eadie
Journal:  Drugs Aging       Date:  1997-04       Impact factor: 3.923

Review 6.  Treating epilepsy in the elderly: safety considerations.

Authors:  S Arroyo; G Kramer
Journal:  Drug Saf       Date:  2001       Impact factor: 5.606

Review 7.  Pharmacokinetic optimisation of drug therapy in elderly patients.

Authors:  B M Parker; B J Cusack; R E Vestal
Journal:  Drugs Aging       Date:  1995-07       Impact factor: 3.923

8.  Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy.

Authors:  Ghada F Ahmed; Richard C Brundage; Susan E Marino; James C Cloyd; Ilo E Leppik; Page B Pennell; R Eugene Ramsay; Angela K Birnbaum
Journal:  J Clin Pharmacol       Date:  2013-02-13       Impact factor: 3.126

9.  Management of seizures in the elderly: a survey of UK geriatricians.

Authors:  I H Stolarek; A F Brodie; M J Brodie
Journal:  J R Soc Med       Date:  1995-12       Impact factor: 18.000

10.  Deproteinization as a Rapid Method of Saliva Purification for the Determination of Carbamazepine and Carbamazepine-10,11 Epoxide.

Authors:  Ewelina Dziurkowska; Marek Wesolowski
Journal:  J Clin Med       Date:  2020-03-27       Impact factor: 4.241
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.