Epidemiology, Risk Factors and Etiology of Altered Level of Consciousness Among Patients Attending the Emergency Department at a Tertiary Hospital in Mogadishu, Somalia.

Introduction: An altered level of consciousness (ALOC) means that the patient is not as awake, alert, or able to understand or react to the surrounding environment. The main purpose of this study was to investigate the epidemiology, risk factors, and etiology of altered levels of consciousness among patients attending the Emergency Department.
Methods: The study was conducted in the Mogadishu-Somali-Turkey Training and Research Hospital in Mogadishu, Somalia, as a prospective observational study. A total of 155 adult patients with a GCS ≤12 were admitted to the emergency room for traumatic and non-traumatic ALOC between March and June 2021.
Results: Our study enrolled 155 (2.6%) of the 6000 patients hospitalized in the emergency room. 60% (n = 93) were males and 40% (n = 62) were females. The mean age of the participants was 46.7 ± 22.4 years. The most common presenting features were dyspnea (21.9%), injuries (20%), hemiplegia (16.8%), convulsion (16.8%), and oliguria (12.3%). 119 (77%) cases had a GCS = 3-8, while 36 (23%) had a GCS = 9-12. Most of the participants with ALOC had a history of hypertension (27.7%, n = 43), 34 (21.9%) had diabetes, 6 (3.9%) had epilepsy, and 4 (2.6%) had chronic renal disease. Cerebro-vascular-accidents (24.5%) were the most common cause of ALOC, followed by organ failure and traumatic brain injury (22% each), infections (12.2%), diabetic emergencies, hypoglycemia (11.6%), shock, and status epilepticus (4% each).
Conclusion: Male sex, older age, hypertension, and diabetes were the main risk factors for our study participants, while uremic encephalopathy, ischemic stroke, hemorrhagic stroke, sepsis syndrome, and subdural hematoma were the most common causes of ALOC.

Introduction

An altered level of consciousness (ALOC) is a state of reduced alertness or inability to arouse due to low awareness of the environment.1 Coma is defined as a complete lack of recognition with no response to the surroundings but intact eye-opening and no eye movement.2 Other descriptions of coma are a score of eight on the Glasgow Coma Scale (GCS) or a score of U on the AVPU (Alert, responsive to Voice, responsive to Pain, Unresponsive) scale.3 The predisposing factors of ALOC include hypertension, diabetes, hypercholesterolemia, and chronic organ failure.4 The causes of ALOC were sub-divided into two categories: traumatic (such as a brain injury) and non-traumatic (such as neurological disorders, metabolic diseases, diffuse physiological malfunction of the brain (such as epilepsy or drugs), and psychiatric or functional disorders).5 Emergency room (ER) admissions for ALOC patients represent 6% of all new patients.6 A study performed in Nigeria showed that medical coma accounted for 9.8% (200/2033) of emergency room visits and 3.1% (200/6548) of total hospital admissions.7 The mortality of altered level of consciousness patients in ER is high and strongly related to the underlying cause.8 To our knowledge, there is no study about the epidemiological characteristics, risk factors, and etiology of ALOC in Somalia. The primary purpose of this study was to investigate the epidemiology, risk factors, and etiology of altered levels of consciousness among patients attending the Emergency Department at a Tertiary Hospital in Mogadishu, Somalia.

Method

The study was a prospective observational study done in Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research Hospital, a tertiary hospital in Mogadishu, Somalia. Consecutive adults admitted as the traumatic and non-traumatic ALOC patients who arrived at the emergency room between March 2021 and June 2021 with a GCS 12 or below were prospectively included.9 Young patients (<15 years of age), pregnant women, acute confusion states (delirium), and patients with no definitive diagnosis were excluded from our study.

An altered level of consciousness (ALOC) means that the patient is not as awake, alert, or able to understand or react to the surrounding environment.10 One hundred and fifty-five patients had met the criteria of ALOC. We used a questionnaire-based formula to collect data, and we categorized it into 1) socio-demographic factors including age, gender, and previously known chronic diseases. 2) Clinical presentations included dyspnea, convulsion, fever, oliguria, hemiplegia, diarrhea/vomiting, and injuries. 3) Laboratory investigations included serum blood glucose, arterial blood gases, complete blood count, liver function tests, renal function testing, serum electrolytes (sodium, potassium, calcium, magnesium, and chloride), urine analysis, serum procalcitonin, and C-reactive protein for every ALOC patient admitted to the emergency department. 4) We also evaluated imaging modalities such as computed tomography (CT) of the head first for every unconscious patient with neurological findings to exclude brain hemorrhage. If the brain CT and laboratory data are unremarkable, we concluded brain magnetic resonance imaging (MRI) for the possibility of ischemic stroke. We performed a whole-body CT scan of the head, cervical, thoracic, and abdominopelvic regions for patients with trauma-induced unconsciousness. 4) We performed a chest x-ray, echocardiogram, abdomen, and blood vessels (Doppler) ultrasound as required. 5) The last question of our questionnaire was the etiology of ALOC based on the Glasgow coma scale (GCS), while the diagnostic criteria of ALOC are summarized in Table 1.

Table 1

Common Etiologies of ALOC and Their Diagnostic Criteria

Etiology of ALOC	Diagnostic Criteria
Uremic encephalopathy	A history of renal dialyses, abnormal serum electrolytes (bicarbonate <15 mmol/L, potassium >5.5 mmol/L), creatinine (>10mg/dl), and urea (>300mg//dl) and features of chronic renal failure.11
Stroke (ischemic and hemorrhagic)	Features of focal neurological signs, decreased level of consciousness, non-contrast CT head showing cerebral hemorrhage/ischemic infarct, or presence of focal neurological signs with normal CT brain but ischemic infarct on Brain MRI.12
Sepsis syndrome	Suspected or confirmed infection, signs of systemic inflammation, and evidence of new organ dysfunction and/or tissue hypoperfusion, as well as an increase of 2 points or more of the Sequential Organ Failure Assessment (SOFA) score from baseline.13
Hepatic encephalopathy	It’s an exclusionary diagnosis with Increased liver function tests, prothrombin time, and decreased serum proteins; aberrant changes of liver size and architecture on ultrasonography as well as symptoms of severe fulminant hepatitis and hepatic failure.14,15
Hypoglycemia	Whipple’s triad was used to diagnose hypoglycemia clinically: hypoglycemia symptoms, plasma glucose concentration <55 mg/dl, and symptoms resolve once plasma glucose concentration is corrected.16
Diabetic coma	DKA: a blood glucose level of >250 mg/dl, an anion gap of >12 mEq/L, a bicarbonate level of <15 mEq/L, and a pH <7.3 with substantial ketonuria or ketonemia.17 HHS is characterized by serum glucose levels of >600 mg/dl, a high estimated plasma osmolality of ≥320 mOsm/kg, serum bicarbonate levels of >15 mEq/L, an arterial pH of >7.3, and serum ketones that range from negative to slightly positive.18
Shock	Evidence of inadequate tissue perfusion (depressed levels of awareness, oliguria, and peripheral cyanosis) and symptoms of compensatory mechanisms are used to diagnose shock (tachycardia, tachypnea, and diaphoresis). Systolic blood pressure (<90 mm Hg), lactate > 3 mmol/l and urine output <0.5 mL/kg/hr.19
Status epileptics	We considered status epilepticus as a seizure lasting longer than 5 minutes or having more than one episode of seizure within a 5-minute period without returning to a normal level of awareness between episodes, positive EEG and responds to antiepileptic drugs.20,21
Meningitis	A mixture of clinical feature such as neck stiffness, convulsion, fever, decreased mental status, and lumber puncture result with elevated white blood cells, increased protein and low glucose level.22,23
Decompensated heart failure	We considered decompensated heart failure (DHF) if there is dyspnea, orthopnea, chest pain, decreased mental status, jugular venous distension, bilateral basal crepitation, chest x-ray finding of bilateral consolidation (pulmonary edema) and echocardiography finding of low ejection fraction (EF) or diastolic heart failure.24,25
Traumatic coma	We used brain CT scan for all head trauma patients, as well as neck, chest and abdomino-pelvic CT scan to reach the diagnoses of ALOC.26

The study was approved by the local ethical committee board of Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research Hospital with a reference number of MSTH/5198, and written informed consent was obtained from the patient’s relatives.

The Statistical Package for Social Sciences application was used to conduct statistical analyses (SPSS version 23.0). The mean and standard deviation of numeric variables had presented. Percentages had used to represent nominal variables. Cross tabulation had utilized to examine differences across groups and determine the cause of ALOC. Fisher's exact test was utilized for categorical variables to compare patient characteristics between groups. P < 0.05 was considered statistically significant.

Results

155 (2.6%) out of 6000 patients admitted to the emergency unit had enrolled in our study. 60% (n = 93) were males and 40% (n = 62) were females. The mean age of the participants was 46.7 (SD± 22.4) years with the minimum and the maximum age was 15–91 years. According to the age group, 39 (25.2%) patients were in between 15 and 25 years, 36 (23.2%) patients were 26–45 years, 29 (18.7%) patients were 46–60 years, while 51 (32.9%) patients were >60 years with male predominance 31 out of 51 cases and this age group constitutes the most respondents of this study.

Figure 1 summarizes the risk factors of ALOC among participants. Most (27.7%, n = 43) of participants with ALOC had a history of hypertension. 34 (21.9%) had diabetes, 6 (3.9%) had epilepsy, 4 (2.6%) chronic renal disease (CRD), 3 (1.9%) chronic liver disease (CLD), and 1 (0.6%) had chronic obstructive pulmonary disease (COPD). Nearly half of the participants (41.3%, n = 64) had no risk factor.

Figure 1

Risk factors of ALOC among participants.

The most common presenting features were dyspnea 34 (21.9%), injuries 31 (20%), hemiplegia 26 (16.8%), convulsion 26 (16.8%), oliguria 19 (12.3%), fever 17 (11%), and diarrhea/vomiting 2(1.3%). Among the 155 participants, their Glasgow coma scale (GCS) had distributed as follows: 26 (16.8%) respondents had a GCS = 3, 93 (60%) respondents had a GCS 4–8, this constituted the most frequency group, and 36 (23.2%) respondents had moderate GCS 9–12.

In our diagnostic method, 112 (72.3%) cases had a chest x-ray, 94 (60.6%) cases had a brain CT, 32 (20.6%) cases had a neck CT, 38 (24.5%) cases had thorax CT, 40 (25.8%) cases had abdominopelvic CT, 19 (12.3%) cases had brain MRI, 15 (9.4%) cases had echocardiography, 50 (32.3%) cases had abdominal USG, and 13 (8.4%) cases had Doppler USG (Table 2).

Table 2

Distribution of Age, Gender, Risk Factors, Clinical Features, GCS, Radiology and Etiology

Variables			Frequency (n)	Percentage (%)
Age	46.7 ± 22.4 (15–91) years
Age group (years)	15–25		29	25.2
	26–45		36	23.2
	46–60		29	18.7
	>60		51	32.9
Gender	Male		93	60
	Female		62	40
Risk factors	Yes		91	58.7
	No		64	41.3
Clinical features	Dyspnea		34	21.9
	Injuries		31	20
	Hemiplegia		26	16.8
	Convulsion		26	16.8
	Oliguria		19	12.3
	Fever		17	11
	Diarrhea/vomiting		2	1.3
GCS (3–12)	9–12		36	23.2
	4–8		93	60
	3		26	16.8
Imaging & intervention	Chest x-ray		112	72.3
	CT-scan	Brain	94	60.6
		Cervical	32	20.6
		Thorax	38	24.5
		Abdomino-pelvic	40	25.8
	Brain MRI		19	12.3
	Ultrasonography (USG)	Echocardiography	15	9.7
		Abdomen	50	32.3
		Doppler USG	13	8.4
	Electroencephalography (EEG)		10	6.5
	Lumber puncture (LP)		4	2.6
Etiology of ALOC	Non-traumatic		123	79.4
	Traumatic		32	20.6

Abbreviations: GCS, Glasgow coma scale; CT, computed tomography; MRI, magnetic resonance imaging.

A total of 13 non-traumatic (medical) and 5 traumatic causes of ALOC are summarized in Figure 2; these include 23 (14.8%) with uremic encephalopathy, 21 (13.5%) with ischemic stroke, 17 (10.9%) with hemorrhagic stroke, 15 (9.7%) with sepsis syndrome, 12 (7.7%) subdural hematoma, 10 (6.5%) with diabetic emergencies (DKA & HHS), 9 (5.8%) with hepatic encephalopathy, 8 (5.2%) with hypoglycemia, 7 (4.5%) with diffuse axonal injury, 6 (3.9%) with status epileptics, 6 (3.9%) with shock, 6 (3.9%) with traumatic SAH, 4 (2.6) % with epidural hematoma, 4 (2.6%) with meningitis, 3 (1.9%) traumatic ICH, 2 (1.3%) with hyponatremia, and 2 (1.3%) with decompensated heart failure (DHF).

Figure 2

Etiology of altered level of consciousness among participants.

According to the laboratory results, the majority of ALOC patients showed respiratory alkalosis, increased serum creatinine, urea, AST, ALT, CRP, and Procalcitonin. PH, HCO3, Creatinine, Urea, AST, ALT, CRP, and Procalcitonin mean 7.630.41, 17.640.55, 13.570.34, 97.678.80, 167.4929.98, 166.6632.92, 88.998.21, and 3.630.67, respectively, as shown in Table 3.

Table 3

Laboratory Findings of the Respondents

Variable	Mean ± SD	Normal Range
pH	7.63 ± 0.41	7.35–7.45
PCO2	39.11 ± 1.28	35–45
HCO3	17.64 ± 0.55	22–28
WBC (×1000/mm3)	16.82 ± 0.78	4–10
Hb (g/dl)	10.81 ± 0.22	12–16
PLT (×1000/mm3)	193.28 ± 8.21	100–430
Glucose (mg/dl)	175.56 ± 14.23	60–110
Creatinine (mg/dl)	13.57 ± 0.34	0.5–1.35
Urea (mg/dl)	97.67 ± 8.80	10–45
AST (U/L)	167.49 ± 29.98	0–31
ALT (U/L)	166.66 ± 32.92	0–45
Sodium (mEq/L)	136.33 ± 0.77	135–150
Potassium (mEq/L)	4.79 ± 0.11	3.5–5.5
CRP (mg/l)	88.99 ± 8.21	0–10
Procalcitonin (ng/mL)	3.63 ± 0.67	<0.5
INR	1.87 ± 0.08	0.8–1.2

Abbreviations: PCO2, partial pressure of carbon dioxide; HCO3, bicarbonate; WBC, white blood cells; Hb, hemoglobin; PLT, platelets; AST, aspartate aminotransferase; ALT, alanine transaminase; CRP, C-reactive proteins; INR, international normalized ratio.

As indicated in Table 4, uremic encephalopathy, ischemic stroke, hemorrhagic stroke, subdural hematoma, status epilepticus, DKA, diffuse axonal damage, traumatic SAH, epidural hematoma, and meningitis were all more common in men, while sepsis syndrome, shock, traumatic ICH, and hyponatremia were female predominant. Hypoglycemia, HHS, and decompensated HF had distributed equally.

Table 4

Etiological Correlation of ALOC by Sex and GCS

Variable		Altered Level of Consciousness
		Total (n = 155) Freg (%)	Sex (n) Freq (%)			GCS (n) Freq (%)
			Male	Female	P-value	=3	4–8	9–12	P-value
Etiology of ALOC	Uremic encephalopathy	23 (14.8)	17 (11)	6 (3.9)	0.078	2 (1.3)	13 (8.4)	8 (5.2)	0.041*
	Ischemic stroke	21 (13.5)	12 (7.7)	9 (5.8)	0.603	5 (3.2)	9 (5.8)	7 (4.5)	0.908
	Hemorrhagic stroke	17 (10.9)	9 (5.8)	8 (5.2)	0.214	3 (1.9)	13 (8.4)	1 (0.6)	0.267
	Sepsis syndrome	15 (9.7)	6 (3.9)	9 (5.8)	0.000**	9 (5.8)	1 (0.6)	9 (5.8)	0.050*
	Subdural hematoma	12 (7.7)	8 (5.2)	4 (2.6)	0.050*	1 (0.6)	6 (3.9)	5 (3.2)	0.140
	Hepatic encephalopathy	9 (5.8)	6 (3.9)	3 (1.9)	0.072	1 (0.6)	5 (3.2)	3 (1.9)	0.022*
	Hypoglycemia	8 (5.2)	4 (2.6)	4 (2.6)	0.008*	2 (1.3)	4 (2.6)	2 (1.3)	0.666
	DKA	8 (5.2)	5 (3.2)	3 (1.9)	0.001*	1 (0.6)	2 (1.3)	5 (3.2)	0.026*
	Diffuse axonal injury	7 (4.5)	4 (2.6)	3 (1.9)	0.181	0 (0)	6 (3.9)	1 (0.6)	0.591
	Status epilepticus	6 (3.9)	6 (3.9)	0 (0)	0.000**	0	5 (3.2)	1 (0.6)	0.156
	Shock	6 (3.9)	2 (1.3)	4 (2.6)	0.768	2 (1.3)	4 (2.6)	0 (0)	0.982
	Traumatic SAH	6 (3.9)	4 (2.6)	2 (1.3)	0.000**	0	5 (3.2)	1 (0.6)	0.766
	Epidural hematom	4 (2.6)	4 (2.6)	0 (0)	0.016*	1 (0.6)	2 (1.3)	1 (0.6)	0.918
	Meningitis	4 (2.6)	3 (1.9)	1 (0.6)	0.004*	2 (1.3)	2 (1.3)	0 (0)	0.509
	Traumatic ICH	3 (1.9)	1 (0.6)	2 (1.3)	1.000	0	3 (1.9)	0 (0)	0.431
	Hyponatremia	2 (1.3)	0 (0)	2 (1.3)	0.007*	1 (0.6)	1 (0.6)	0 (0)	0.014*
	HHS	2 (1.3)	1 (0.6)	1 (0.6)	0.564	0	2 (1.3)	0 (0)	0.268
	DHF	2 (1.3)	1 (0.6)	1 (0.6)	0.206	0	2 (1.3)	0 (0)	0.835

Note: *Significance correlation, **Strong significance correlation.

Abbreviations: DKA, diabetic ketoacidosis; SAH, subarachnoid hemorrhage; ICH, intracerebral hemorrhage; HHS, hyperglycemic hyperosmolar syndrome; DHF, decompensated heart failure.

Sepsis syndrome, subdural hematoma, hypoglycemia, DKA, status epilepticus, traumatic SAH, epidural hematoma, meningitis and hyponatremia were showed significant association with gender (p < 0.000**, p < 0.050*, p < 0.008*, p < 0.001*, p < 0.000*, p < 0.000**, p < 0.016*, p < 0.004*, and p < 0.007*), respectively.

For GCS = 3, the association between an ALOC and GCS showed that 5 (3.2%) patients had sepsis syndrome, 5 (3.2%) cases had an ischemic stroke, 3 (1.9%) cases had a hemorrhagic stroke, 2 (1.2%) cases had uremic encephalopathy, and 2 (1.2%) had hypoglycemia. A GCS of 4–8, on the other hand, indicated that 13 (8.4) patients had uremic encephalopathy, 13 (8.4) patients had a hemorrhagic stroke, 9 (5.8) patients had an ischemic stroke, 9 (5.8) patients had sepsis, 6 (3.9) patients had a subdural hematoma, and 6 (3.9) patients had a diffuse axonal injury. While those with GCS = 9–12 were 5.2% (n = 8), 4.5% (n = 7), 3.2% (n = 5), 3.2% (n = 5), and 1.9% (n = 3), uremic encephalopathy, ischemic stroke, subdural hematoma, DKA, and hepatic encephalopathy, respectively (Table 4).

Uremic encephalopathy, sepsis syndrome, hepatic encephalopathy, DKA, and hyponatremia were significantly associated with GCS (p < 0.04*, p < 0.05*, p < 0.022*, p < 0.026*, and p < 0.014*), respectively.

Table 5 shows that the majority of the study respondents (n = 91, 58.7%) had a one or more comorbidities. Most of the respondent (n = 43, 27.7%) had hypertension, followed by diabetes (n = 34, 22%), and epilepsy (n = 6, 3.9%). 27 (17.4%) patients with hypertension were predominant in the age older than 60 years, followed by the age group of 26–45 and 46–60 (n = 7, 4.5% each). On the other hand, diabetes was more common in patients with age of 60 years and 46–60, 11% and 10.7%, respectively.

Table 5

Correlation Between Risk Factors and Age Group Among Patients with ALOC

Variables		Age Group (Years)
		15–25	26–45	46–60	>60	P-value
Hypertension	Yes	2	7	7	27	0.000**
	No	37	29	22	24
Diabetes	Yes	4	1	12	17	0.000**
	No	35	35	17	34
Epilepsy	Yes	4	1	1	0	0.091
	No	35	35	28	51
ESRD	Yes	0	0	2	2	0.212
	No	39	36	27	49
CLD	Yes	0	1	2	0	0.129
	No	39	35	27	51
COPD	Yes	0	0	1	0	0.224
	No	39	36	28	51

Note: **Strong significance correlation.

A strong significant association was found between risk factor of hypertension and age group (P = 0.000**) and also diabetes and age group (P = 0.000**).

Discussion

There are several admissions for ALOC to the emergency room (ER) due to trauma-related unconsciousness such as subdural hematoma and non-trauma (medical coma) cases like uremic encephalopathy, Cerebrovascular accident (CVA), and sepsis syndrome. The diagnosis of ALOC had reached using family history, physical examinations including GCS, medical pictures (brain CT scan, brain MRI, USG, and chest x-ray), and the results of laboratory tests.

In the present study, we found that 2.6% of ALOC patients had been admitted to the emergency department during a four-month study period. Similar to our report, William et al reported that approximately 5% of unconscious patients visited the emergency room within four months.27 Our study excluded all unconscious patients with their GCS >12 and acute confusional state, in contrast to William and his colleagues’ study.27

The mean age of our study participants was 46.7 ± 22.4 years, while >60 years of the age group constituted the uppermost and most cases were male sex (60%), specifically older males. A study with the same focus performed by Nasution et al showed that the mean age was 41.65 ± 19.5 years old, 57.8% were males, and most study participants were older males.6

Data carried out in Nigeria showed that male sex, hypertension, diabetes, obesity, and substance abuse, positive hepatitis B virus (HBV), and human immunodeficiency virus (HIV) were the most common risk factors among ALOC patients.7 In the current study, sixty percent of ALOC patients had at least one risk disease involving hypertension, diabetes, epilepsy, chronic renal disease, chronic liver disease, and COPD. There are a few differences between the two studies, substance abuse (alcohol) and HIV were not common in our study population. In the current study, there is a significant link between ALOC and hypertension and also ALOC and diabetes (P < 000** each) as shown in Table 5.

According to Volk and his friend’s study, the most common clinical symptoms in our report were dyspnea 34 (21.9%), injuries 31 (20%), hemiplegia 26 (16.8%), convulsion 26 (16.8%), oliguria 19 (12.3%), fever 17 (11%), and diarrhea/vomiting 2 (1.3%).28

According to the severity of ALOC patients based on GCS, a Munich study found that 15% had a GCS 3–8 and 23% had a GCS 9–12 but had not been classified as etiology-based GCS.28 In contrast to the previous study, in the present study, 119 (77%) cases had a GCS = 3–8, while the remaining 36 (23%) had a GCS = 9–12. Most of our cases were organ failure-induced ALOC (22%, n = 34), cerebrovascular accident (24.5%, n = 38), and traumatic brain injury (20.6%, n = 32).

In the current study, the most common causes of altered level of consciousness were cerebrovascular accidents (CVA) (24.5%), organ failure (OF) and traumatic brain injury (22% each), infections (12.2%), diabetic emergencies and hypoglycemia (11.6%), and shock and status epilepticus (4% each). To consider a study from Nigeria, four common causes of ALOC were acute stroke, diabetic crises, uremic encephalopathy, and infections; 33%, 12.5%, 11%, and 11%, respectively.7 Another report from Sweden revealed 24% had a focal neurological lesion (stroke), 21% had metabolic disturbance, 12% had epileptic coma.29 A similar study appeared cerebrovascular disorders were the most trusted causes of ALOC (24%), particularly ischemic stroke was uppermost in this group, followed by infections (14%), metabolic and cardiovascular disease (13%), epileptic seizures (12%), and trauma (2%).28 In trauma-related ALOC, there is a considerable difference between our study and other studies from developed countries since our country has high rates of explosions, gunshot, and road traffic accidents, while developed countries (Germany) have no or low rate explosions and gunshots. So our study discovered a high prevalence of trauma-related ALOC which constituted 22% (n = 32) when compared to the study from Germany 2% (n = 4).28

There are two strengths of our study results. First, we measured the association between the GCS and the etiological distribution of ALOC. We demonstrated that patients with a GCS 4–8 had uremic encephalopathy, ischemic stroke, hemorrhagic stroke, sepsis syndrome, subdural hematoma, and diffuse axonal injury. Second, we looked at the link between ALOC etiological distributions and sex. Uremic encephalopathy, ischemic stroke, hemorrhagic stroke, subdural hematoma, status epilepticus, diffuse axonal damage, traumatic SAH, epidural hematoma, and meningitis were the most common male cases. Sepsis syndrome, shock, traumatic ICH, and hyponatremia had predominant in females, while diabetic crises and decompensated HF were shown to have equal sex distribution.

Our study has several limitations; first, the study had done in a single tertiary hospital that cannot represent the clear image of ALOC in our target population. Second, the duration of our study was four months which was not enough to reach conclusive results. Third, the sample size of our cases was 155 which is relatively small. Finally, some parameters that did not examine (intoxications, body mass index (BMI), and smoking), as well as pregnancy and acute confusional state or delirium, were excluded.

Conclusion

The current study sheds light on the risk factors and etiology of ALOC. Male sex, older age, hypertension, diabetes, and trauma were the main risk factors for our study participants. The severity of the patients with ALOC based on GCS, 119 (77%) cases had a GCS = 3–8 which constitutes the uppermost level. The most common causes of ALOC in the adult patients admitted to the ER were uremic encephalopathy, ischemic stroke, hemorrhagic stroke, sepsis syndrome, and subdural hematoma.

Recommendation

Our study suggests that men and older people initiate lifestyle changes and maintain a careful follow-up to their health. Also, we prose to practice preventive measures and attend regular medical checkups among patients with chronic diseases including systemic hypertension, diabetes, epilepsy, and COPD. Finally, we recommend performing original research about predisposing variables, the pathogenesis of renal failure, and renal replacement method in Somalia since renal failure was the most common cause of ALOC.