Literature DB >> 3566884

Lidocaine toxicity after maternal pudendal anesthesia in a term infant with fetal distress.

M E Bozynski, L B Rubarth, J A Patel.   

Abstract

There have been many reports of lidocaine toxicity especially after maternal paracervical block anesthesia. We recently treated a term infant with evidence of fetal distress who presented with symptoms of lidocaine toxicity after maternal pudendal anesthesia. The infant developed apnea and bradycardia soon after birth which responded to mechanical ventilation and epinephrine. A prolonged Q-T interval was noted on day 1 which normalized by day 3. Cord blood was assayed and revealed an elevated lidocaine level. Lidocaine toxicity has been associated with fetal distress secondary to fetal ion trapping in the presence of acidosis. Although good response to supportive therapy occurred in our patient, other methods of therapy such as exchange transfusion and treatment of seizures may be required in some cases. Awareness of this now uncommon syndrome will lead to prompt diagnosis, appropriate work-up, and management.

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Year:  1987        PMID: 3566884     DOI: 10.1055/s-2007-999764

Source DB:  PubMed          Journal:  Am J Perinatol        ISSN: 0735-1631            Impact factor:   1.862


  3 in total

Review 1.  Retroperitoneal hematoma as a complication of pudendal block. Diagnosis made by computed tomography.

Authors:  R B Kurzel; A H Au; S A Rooholamini
Journal:  West J Med       Date:  1996-06

Review 2.  Update in fetal anesthesia for the ex utero intrapartum treatment (EXIT) procedure.

Authors:  Pornswan Ngamprasertwong; Alexander A Vinks; Anne Boat
Journal:  Int Anesthesiol Clin       Date:  2012

Review 3.  Drug Transporters Expressed in the Human Placenta and Models for Studying Maternal-Fetal Drug Transfer.

Authors:  André Dallmann; Xiaomei I Liu; Gilbert J Burckart; John van den Anker
Journal:  J Clin Pharmacol       Date:  2019-09       Impact factor: 3.126

  3 in total

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