Literature DB >> 35668049

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Year:  2022        PMID: 35668049      PMCID: PMC9170811          DOI: 10.1111/jcmm.17329

Source DB:  PubMed          Journal:  J Cell Mol Med        ISSN: 1582-1838            Impact factor:   5.295


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In Nie et al, the TEM image of the MI +MCC950 + H2 group in Figure 2H and the Masson local image for the MI +MCC950 + H2 group in Figure 3A cannot be used as representative images. The correct figure is shown below. The authors confirm all results and conclusions of this article remain unchanged.
FIGURE 2

Effects of H2 inhalation on cardiac function and myocardial structure changes in rats. (A) Survival curve of rats of each experimental group; (B) the plasma BNP concentration of each group, n = 5 per group; (C) images illustrating echocardiography of rat's heart; (D–G) EF (%); FS (%); LVIDd and LVIDs (n = 5 per group); (H) TEM images illustrating the cardiomyocytes (×30k magnification, scale bar 100 nm), the arrow indicates the mitochondria of cardiomyocytes; (I) the heart MDA concentration of each group, n = 5 per group; (J) the heart relative ·OH concentration of each group, n = 5 per group. Data are shown by mean ± SEM, ***p < 0.001 vs Sham group. #p < 0.05 ##p < 0.01 ###p < 0.001 vs MI group. &p < 0.05 vs MI + MCC950 group. $$$p < 0.001 vs MI + MCC950 group

FIGURE 3

Effects of inhalation of H2 on myocardial fibrosis and fibrosis‐related proteins in MI rats. (A) The representative Masson images of rat whole heart and left ventricle; (B) fibrosis area of whole heart sections. n = 5 per group; (C) collagen volume fraction of left ventricle. n = 5 per group; (D) the representative immunohistochemical staining images of α‐SMA and fibronectin expression in each group (×20 magnification, scale bar 50 μm); (E–F) quantification of α‐SMA and fibronectin‐positive cells statistical chart, n = 5 per group; (G) the representative Western blot bands of TGF‐β, α‐SMA, Col I and Col III; (H–K) relative TGF‐β, α‐SMA, Col I and Col III protein level, n = 5. Data are shown by mean ± SEM, ***p < 0.001 vs Sham group. #p < 0.05 ##p < 0.01 ###p < 0.001 vs MI group. &p < 0.05 vs MI +MCC950 group

Effects of H2 inhalation on cardiac function and myocardial structure changes in rats. (A) Survival curve of rats of each experimental group; (B) the plasma BNP concentration of each group, n = 5 per group; (C) images illustrating echocardiography of rat's heart; (D–G) EF (%); FS (%); LVIDd and LVIDs (n = 5 per group); (H) TEM images illustrating the cardiomyocytes (×30k magnification, scale bar 100 nm), the arrow indicates the mitochondria of cardiomyocytes; (I) the heart MDA concentration of each group, n = 5 per group; (J) the heart relative ·OH concentration of each group, n = 5 per group. Data are shown by mean ± SEM, ***p < 0.001 vs Sham group. #p < 0.05 ##p < 0.01 ###p < 0.001 vs MI group. &p < 0.05 vs MI + MCC950 group. $$$p < 0.001 vs MI + MCC950 group Effects of inhalation of H2 on myocardial fibrosis and fibrosis‐related proteins in MI rats. (A) The representative Masson images of rat whole heart and left ventricle; (B) fibrosis area of whole heart sections. n = 5 per group; (C) collagen volume fraction of left ventricle. n = 5 per group; (D) the representative immunohistochemical staining images of α‐SMA and fibronectin expression in each group (×20 magnification, scale bar 50 μm); (E–F) quantification of α‐SMA and fibronectin‐positive cells statistical chart, n = 5 per group; (G) the representative Western blot bands of TGF‐β, α‐SMA, Col I and Col III; (H–K) relative TGF‐β, α‐SMA, Col I and Col III protein level, n = 5. Data are shown by mean ± SEM, ***p < 0.001 vs Sham group. #p < 0.05 ##p < 0.01 ###p < 0.001 vs MI group. &p < 0.05 vs MI +MCC950 group
  1 in total

1.  Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats.

Authors:  Chaoqun Nie; Rentong Zou; Shuang Pan; Rong A; Yunan Gao; Hongxiao Yang; Juncai Bai; Shuiqing Xi; Xue Wang; Xiaojian Hong; Wei Yang
Journal:  J Cell Mol Med       Date:  2021-08-16       Impact factor: 5.310

  1 in total

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