Literature DB >> 3566711

Activation of Na+/H+ exchange in human platelets stimulated by thrombin and a phorbol ester.

W Siffert, G Siffert, P Scheid.   

Abstract

We have investigated changes in cytoplasmic pH (pHi) in activated human platelets, using the fluorescent probe 2,7-biscarboxyethyl-5(6)-carboxyfluorescein. Stimulation of platelets by thrombin or 12-O-tetradecanoylphorbol 13-acetate increased pHi by about 0.11 pH unit above the resting value. This increase in pHi depended on the presence of external Na+ and was inhibited by ethylisopropylamiloride. The data suggest that protein kinase C mediates Na+/H+ exchange in human platelets.

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Year:  1987        PMID： 3566711      PMCID： PMC1147557          DOI： 10.1042/bj2410301

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

Review 1.  Effects of growth factors on intracellular pH regulation.

Authors:  W H Moolenaar
Journal:  Annu Rev Physiol       Date:  1986       Impact factor: 19.318

Review 2.  Metabolic regulation via intracellular pH.

Authors:  W B Busa; R Nuccitelli
Journal:  Am J Physiol       Date:  1984-04

3.  Changes in cytoplasmic pH and in membrane potential in thrombin-stimulated human platelets.

Authors:  W C Horne; N E Norman; D B Schwartz; E R Simons
Journal:  Eur J Biochem       Date:  1981-11

4.  Movement of sodium into human platelets.

Authors:  W C Sandler; G C Le Breton; H Feinberg
Journal:  Biochim Biophys Acta       Date:  1980-08-04

5.  Movement of sodium into human platelets induced by ADP.

Authors:  H Feinberg; W C Sandler; M Scorer; G C Le Breton; B Grossman; G V Born
Journal:  Biochim Biophys Acta       Date:  1977-10-17

6.  Thrombin stimulates Na+-H+ exchange across the human platelet plasma membrane.

Authors:  W Siffert; G Fox; K Mückenhoff; P Scheid
Journal:  FEBS Lett       Date:  1984-07-09       Impact factor: 4.124

7.  Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

Authors:  B W Agranoff; P Murthy; E B Seguin
Journal:  J Biol Chem       Date:  1983-02-25       Impact factor: 5.157

8.  Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

Authors:  K Kaibuchi; Y Takai; M Sawamura; M Hoshijima; T Fujikura; Y Nishizuka
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157

9.  [3H]ethylpropylamiloride, a radio-labelled diuretic for the analysis of the Na+/H+ exchange system. Its use with kidney cell membranes.

Authors:  P Vigne; C Frelin; M Audinot; M Borsotto; E J Cragoe; M Lazdunski
Journal:  EMBO J       Date:  1984-11       Impact factor: 11.598

10.  Cytoplasmic pH and free Mg2+ in lymphocytes.

Authors:  T J Rink; R Y Tsien; T Pozzan
Journal:  J Cell Biol       Date:  1982-10       Impact factor: 10.539
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  14 in total

1.  Agonist-evoked changes in cytosolic pH and calcium concentration in human platelets: studies in physiological bicarbonate.

Authors:  S O Sage; T M Jobson; T J Rink
Journal:  J Physiol       Date:  1990-01       Impact factor: 5.182

2.  Phosphorylation-dependent and -independent pathways of platelet aggregation.

Authors:  S P Watson; S Hambleton
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

3.  Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets.

Authors:  W G King; G L Kucera; A Sorisky; J Zhang; S E Rittenhouse
Journal:  Biochem J       Date:  1991-09-01       Impact factor: 3.857

4.  Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activation.

Authors:  Robert Bucki; Jennifer J Pastore; Françoise Giraud; Paul A Janmey; Jean-Claude Sulpice
Journal:  Biochim Biophys Acta       Date:  2006-01-17

5.  Activation of Na+/H+ exchange and Ca2+ mobilization start simultaneously in thrombin-stimulated platelets. Evidence that platelet shape change disturbs early rises of BCECF fluorescence which causes an underestimation of actual cytosolic alkalinization.

Authors:  W Siffert; G Siffert; P Scheid; J W Akkerman
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

Review 6.  Sodium-hydrogen exchange and platelet function.

Authors:  D Rosskopf
Journal:  J Thromb Thrombolysis       Date:  1999-07       Impact factor: 2.300

7.  Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+.

Authors:  M M Davidson; R J Haslam
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

8.  Na+/H+ exchange in human lymphocytes and platelets in chronic and subacute metabolic acidosis.

Authors:  H P Reusch; R Reusch; D Rosskopf; W Siffert; J F Mann; F C Luft
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

9.  Intracellular calcium mobilization and activation of the Na+/H+ exchanger in platelets.

Authors:  E Poch; A Botey; J Gaya; A Cases; F Rivera; L Revert
Journal:  Biochem J       Date:  1993-03-01       Impact factor: 3.857

10.  Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells.

Authors:  L Juntti-Berggren; P Rorsman; W Siffert; P O Berggren
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857
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