| Literature DB >> 35666046 |
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Abstract
Entities:
Year: 2022 PMID: 35666046 PMCID: PMC9288789 DOI: 10.1002/ehf2.14007
Source DB: PubMed Journal: ESC Heart Fail ISSN: 2055-5822
Typical false‐positive and false‐negative cases in planar 99mTc‐PYP scintigraphy for the diagnosis of ATTR‐CM
| Planar 99mTc‐PYP scintigraphy results | Potential causes of false results |
|---|---|
| False positive |
AL amyloidosis AApoAI, AApoAII, AApoAIV, and Aβ2M Hypertrophic cardiomyopathy Hydroxychloroquine toxicity Cardiac blood pool Intravenous iron injections |
| False negative |
ATTRv‐CM with a low sensitivity in scintigraphy (Ser77Tyr or Phe64Leu mutation) Initial diagnosis of cardiac pools with myocardial deposits |
Potential causes of inconsistencies between planar 99mTc‐PYP scintigraphy and biopsy findings in suspected ATTR‐CM
| Planar 99mTc‐PYP scintigraphy | Biopsy | Potential causes of inconsistencies |
|---|---|---|
| Positive | Negative |
Sampling errors in biopsy Errors in scintigraphy imaging time or evaluation Errors in pathological diagnosis Cardiac pools Deposit of proteins other than transthyretin (e.g. AL) |
| Negative | Positive |
Errors in scintigraphy evaluation Errors in pathological diagnosis Deposit of proteins other than transthyretin (e.g. AL) ATTRv‐CM with a low sensitivity in 99mTc‐PYP scintigraphy ( |