Literature DB >> 3566257

Concentration of norfloxacin in human gallbladder tissue and bile after single-dose oral administration.

M Dan, F Serour, A Gorea, A Levenberg, M Krispin, S A Berger.   

Abstract

Concomitant concentrations of norfloxacin in serum and in gallbladder tissue and bile were determined in 10 patients after a single oral dose of 400 mg given before cholecystectomy. Concentrations in gallbladder bile ranged from 0.6 to 15.6 micrograms/ml, with a mean bile/serum ratio of 7.0. The mean concentration in gallbladder tissue was 1.8 +/- 0.8 (standard error) micrograms/g.

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Year:  1987        PMID： 3566257      PMCID： PMC174726          DOI： 10.1128/AAC.31.2.352

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  4 in total

1.  The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro.

Authors:  J S Wolfson; D C Hooper
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191

Review 2.  The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans.

Authors:  D C Hooper; J S Wolfson
Journal:  Antimicrob Agents Chemother       Date:  1985-11       Impact factor: 5.191

Review 3.  Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  B Holmes; R N Brogden; D M Richards
Journal:  Drugs       Date:  1985-12       Impact factor: 9.546

4.  In vitro antibacterial activity of norfloxacin compared with eight other antimicrobial agents.

Authors:  B A Body; R A Fromtling; S Shadomy; H J Shadomy
Journal:  Eur J Clin Microbiol       Date:  1983-06       Impact factor: 3.267
  4 in total
  4 in total

1.  Hepatobiliary kinetics and excretion of ciprofloxacin.

Authors:  M F Parry; D A Smego; M A Digiovanni
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

2.  Pharmacokinetics and biliary concentrations of fleroxacin in cholecystectomized patients.

Authors:  W L Hayton; V Vlahov; N Bacracheva; I Viachki; R Portmann; G Muirhead; K Stoeckel; E Weidekamm
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

Review 3.  Quinolones and the gastrointestinal tract.

Authors:  B E Murray
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-12       Impact factor: 3.267

Review 4.  Fluoroquinolone antimicrobial agents.

Authors:  J S Wolfson; D C Hooper
Journal:  Clin Microbiol Rev       Date:  1989-10       Impact factor: 26.132
  4 in total

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