Literature DB >> 3566185

Characterization of multidrug resistance in SEWA mouse tumor cells: increased glutathione transferase activity and reversal of resistance with verapamil.

B Dahllöf, T Martinsson, B Mannervik, H Jensson, G Levan.   

Abstract

The glutathione transferase (EC 2.5.1.18) activity of multidrug-resistant and drug-sensitive SEWA mouse tumor cells was determined. Increase in activity was found in all multidrug-resistant sublines. Electrophoretic separation of cytosolic proteins and immunodetection, using antisera against Class Alpha, Class Mu and Class Pi glutathione transferase, revealed a two-fold increase of the Class Pi transferase in the resistant cells. The role of glutathione transferase of Class Pi in the multidrug resistance and its distinction from the over-produced 21,000 dalton protein p21 is discussed. Reversal of the resistance, using the calcium antagonist verapamil, and different sensitivity to verapamil between different sublines are also reported.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3566185

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  7 in total

1.  Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi.

Authors:  M Q Islam; A Platz; J Szpirer; C Szpirer; G Levan; B Mannervik
Journal:  Hum Genet       Date:  1989-07       Impact factor: 4.132

2.  Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase.

Authors:  P Di Simplicio; H Jensson; B Mannervik
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

3.  Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933.

Authors:  M A Alaoui Jamali; M B Yin; A Mazzoni; I Bankusli; Y M Rustum
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

4.  Glutathione transferases in rat hepatoma cells. Effects of ascites cells on the isoenzyme pattern in liver and induction of glutathione transferases in the tumour cells.

Authors:  M K Tahir; C Guthenberg; B Mannervik
Journal:  Biochem J       Date:  1989-01-01       Impact factor: 3.857

5.  Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol.

Authors:  D P Danger; W S Baldwin; G A LeBlanc
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

Review 6.  Glutathione S-conjugates as prodrugs to target drug-resistant tumors.

Authors:  Emma E Ramsay; Pierre J Dilda
Journal:  Front Pharmacol       Date:  2014-08-11       Impact factor: 5.810

7.  Enhancement by verapamil of neocarzinostatin action on multidrug-resistant Chinese hamster ovary cells: possible release of nonprotein chromophore in cells.

Authors:  Y Miyamoto; H Maeda
Journal:  Jpn J Cancer Res       Date:  1991-03
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.