| Literature DB >> 35657501 |
Wenyu Xiong1,2, Jie Chen1,2, Junqiang He1,2, Meifang Xiao1,2, Xiaoyu He1,3, Bin Liu4,5,6,7, Feng Zeng8,9,10.
Abstract
The aim of the present study was to investigate the anti-diabetic effect of CGSGCG and its beneficial effects on gut microbiota in type 2 diabetes (T2D) mice induced by streptozotocin and high sucrose and high fat diet. The results showed that treatment with CGSGCG reduced fasting blood glucose, improved oral glucose tolerance test, protected the liver from injury, and reduced inflammation in T2D mice. The contents of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid and isovaleric acid in CGSGCG group were 2.49-, 1.74-, 3.31-, 1.93-, 1.36- and 1.30-fold than that of the model group. Moreover, administration of CGSGCG up-regulated the expression of INSR/IRS-1/PI3K/AKT/GLUT4 and mTOR but down-regulated the P38MAPK expression. Furthermore, the abundance of beneficial bacteria such as Verrucomicrobia, Proteobacteria, Osillibacter, Dubosiella and Lactococcus in intestinal tract increased, indicating that CGSCGG regulated and improved the bacterial community structure of T2D mice, which were closely related to glycometabolism.Entities:
Keywords: Anti-diabetic; Chlorella pyrenoidosa; Gene expression; Glucose metabolism; Gut microbiota
Mesh：
Year: 2022 PMID： 35657501 DOI： 10.1007/s11130-022-00968-1
Source DB: PubMed Journal: Plant Foods Hum Nutr ISSN： 0921-9668 Impact factor: 3.921