W Shi1, C Huang2, S Chen3, C Yang1, N Liu1, X Zhu4, X Su1, X Zhu4, J Lin5,6. 1. Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. 2. Department of Orthopeadics, China-Japan Friendship Hospital, Beijing, China. 3. College of medical imaging, Dalian Medical University, Dalian, China. 4. Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. zhuxs@126.com. 5. Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. linjun@suda.edu.cn. 6. Department of Orthopaedic Surgery, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, China. linjun@suda.edu.cn.
Abstract
To explore the association of air pollution and hip fracture and related mortality in the UK. The average levels of PM2.5, PM10, and NO2 exhibited a positive association with hip fracture and short-term mortality while O3 did not. Our study highlights the association of air pollution and hip fracture. INTRODUCTION: Until now, the influence of air pollution on bone mineral density and associated fractures has drawn little attention, and the consequences are controversial. To investigate the association between air pollution and hip fracture incidence and related short-term mortality. METHODS: We constructed a cohort of all the National Hip Fracture Database beneficiaries (513,540 patients) in the UK from 2013 to 2018. Per year averages of PM2.5, PM10, O3, NO2, and SO2 were estimated according to the person's residence. The incidence rate ratio with 95% confidence interval and all-cause mortality within 30-day post-fracture (ACM30D) rate ratios were estimated using generalized additive models. RESULTS: The average levels of PM2.5, PM10, and NO2 exhibited a positive association with the incidence rate of hip fracture (IHF) and ACM30D. Whereas, this association was negative for O3 levels. Each increase of 5 μg per cubic meter in PM2.5, PM10, and NO2 leads to 9.5%, 9.2%, and 4.1% higher hip fracture rate, respectively, and also 9.3%, 8.3%, and 2.9% higher ACM30D, respectively. When we restricted the analysis to low-level exposure of air pollutants, similar results were obtained. CONCLUSION: Our study found a moderate, positive association between IHF, ACM30D, and the levels of specific air pollutants in the entire National Hip Fracture Database population. A reduction in the levels of PM2.5, PM10, and NO2 may decrease the hip fracture incidence rate and associated short-term mortality in older adults. Our study highlights the influence of air pollution on hip fracture.
To explore the association of air pollution and hip fracture and related mortality in the UK. The average levels of PM2.5, PM10, and NO2 exhibited a positive association with hip fracture and short-term mortality while O3 did not. Our study highlights the association of air pollution and hip fracture. INTRODUCTION: Until now, the influence of air pollution on bone mineral density and associated fractures has drawn little attention, and the consequences are controversial. To investigate the association between air pollution and hip fracture incidence and related short-term mortality. METHODS: We constructed a cohort of all the National Hip Fracture Database beneficiaries (513,540 patients) in the UK from 2013 to 2018. Per year averages of PM2.5, PM10, O3, NO2, and SO2 were estimated according to the person's residence. The incidence rate ratio with 95% confidence interval and all-cause mortality within 30-day post-fracture (ACM30D) rate ratios were estimated using generalized additive models. RESULTS: The average levels of PM2.5, PM10, and NO2 exhibited a positive association with the incidence rate of hip fracture (IHF) and ACM30D. Whereas, this association was negative for O3 levels. Each increase of 5 μg per cubic meter in PM2.5, PM10, and NO2 leads to 9.5%, 9.2%, and 4.1% higher hip fracture rate, respectively, and also 9.3%, 8.3%, and 2.9% higher ACM30D, respectively. When we restricted the analysis to low-level exposure of air pollutants, similar results were obtained. CONCLUSION: Our study found a moderate, positive association between IHF, ACM30D, and the levels of specific air pollutants in the entire National Hip Fracture Database population. A reduction in the levels of PM2.5, PM10, and NO2 may decrease the hip fracture incidence rate and associated short-term mortality in older adults. Our study highlights the influence of air pollution on hip fracture.
Authors: Richard Blomfeldt; Hans Törnkvist; Sari Ponzer; Anita Söderqvist; Jan Tidermark Journal: J Bone Joint Surg Am Date: 2005-08 Impact factor: 5.284
Authors: C Cooper; Z A Cole; C R Holroyd; S C Earl; N C Harvey; E M Dennison; L J Melton; S R Cummings; J A Kanis Journal: Osteoporos Int Date: 2011-04-02 Impact factor: 4.507
Authors: Diddier Prada; Jia Zhong; Elena Colicino; Antonella Zanobetti; Joel Schwartz; Nicholas Dagincourt; Shona C Fang; Itai Kloog; Joseph M Zmuda; Michael Holick; Luis A Herrera; Lifang Hou; Francesca Dominici; Benedetta Bartali; Andrea A Baccarelli Journal: Lancet Planet Health Date: 2017-11-09
Authors: Aaron J Cohen; Michael Brauer; Richard Burnett; H Ross Anderson; Joseph Frostad; Kara Estep; Kalpana Balakrishnan; Bert Brunekreef; Lalit Dandona; Rakhi Dandona; Valery Feigin; Greg Freedman; Bryan Hubbell; Amelia Jobling; Haidong Kan; Luke Knibbs; Yang Liu; Randall Martin; Lidia Morawska; C Arden Pope; Hwashin Shin; Kurt Straif; Gavin Shaddick; Matthew Thomas; Rita van Dingenen; Aaron van Donkelaar; Theo Vos; Christopher J L Murray; Mohammad H Forouzanfar Journal: Lancet Date: 2017-04-10 Impact factor: 79.321