| Literature DB >> 35654389 |
Marilena Bohley1, Andrea E Dillinger2, Ernst R Tamm2, Achim Goepferich3.
Abstract
The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity; and explain why a paradigm shift toward targeted RPE therapy is needed to efficiently fight these retinal diseases. We provide guidance for the development of RPE-specific nanotherapeutics by giving a comprehensive overview of the possibilities and challenges of drug delivery to the RPE and highlight successful nanotherapeutic approaches targeting the RPE.Entities:
Keywords: Age-related macular degeneration; Diabetic retinopathy; Nanotherapy; RPE; Retinal diseases; Retinal pigment epithelium; Retinopathy of prematurity; Targeted drug delivery
Mesh：
Year: 2022 PMID： 35654389 DOI： 10.1016/j.drudis.2022.05.024
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 8.369