Macarena Garrido-Estepa1, Greta Arias-Merino2, Verónica Alonso-Ferreira2,3, Ana Villaverde-Hueso2,3, Manuel Posada de la Paz2. 1. Instituto de Investigación en Enfermedades Raras (IIER), Instituto de Salud Carlos III (ISCIII), Avda, Monforte de Lemos, 5, 28029, Madrid, Spain. mgarrido@isciii.es. 2. Instituto de Investigación en Enfermedades Raras (IIER), Instituto de Salud Carlos III (ISCIII), Avda, Monforte de Lemos, 5, 28029, Madrid, Spain. 3. CIBERER, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Abstract
BACKGROUND: Toxic oil syndrome (TOS) is a multisystemic disease due to a massive intoxication. To evaluate physical and mental health of TOS patients, we used the Health Assessment Questionnaire (HAQ) and the Patient Health Questionnaire-9 (PHQ-9). Additionally, we correlated both questionnaires with the results of the Short Form-36v2 (SF-36v2) Health Survey obtained in the same patients' sample. METHODS: 895 TOS patients who participated in the prior SF-36v2 study were invited to participate. We described patients' demographic and clinical characteristics, HAQ and PHQ-9 results. HAQ and PHQ-9 scores were correlated to the standardised SF-36v2 results obtained in our previous study. RESULTS: In total, 828 (92.5%) TOS annual follow-up and HAQ and 810 (90.5%) PHQ-9 valid questionnaires were analysed. Participants' average age was 65.4 (Standard Deviation (SD): 13.4), 521 (62.9%) were women, 725 (87.6%) reported having at least other chronic disease and 789 (95.3%) an additional TOS-related health problem. Average scores were 0.91 (SD: 0.83) for HAQ, 35.8 (SD: 10.1) for PCS and 37.8 (SD: 11.6) for MCS. Overall, 467 (57.7%) participants had moderate/severe depression (PHQ-9 ≥ 10), but only 229 (49.6%) of them reported having a depression diagnosis. Correlation between questionnaires was very strong for HAQ and physical function SF-36v2 dimension and moderate/fair for the rest of combinations. CONCLUSIONS: TOS cohort presented low/very low health status measured with SF-36v2, moderate difficulties in performing daily activities according to HAQ, and a high prevalence of major depression measured with PHQ-9. High proportion of undiagnosed depression was detected, proving PHQ-9 useful in terms of detecting and promoting depression diagnosis in the cohort.
BACKGROUND: Toxic oil syndrome (TOS) is a multisystemic disease due to a massive intoxication. To evaluate physical and mental health of TOS patients, we used the Health Assessment Questionnaire (HAQ) and the Patient Health Questionnaire-9 (PHQ-9). Additionally, we correlated both questionnaires with the results of the Short Form-36v2 (SF-36v2) Health Survey obtained in the same patients' sample. METHODS: 895 TOS patients who participated in the prior SF-36v2 study were invited to participate. We described patients' demographic and clinical characteristics, HAQ and PHQ-9 results. HAQ and PHQ-9 scores were correlated to the standardised SF-36v2 results obtained in our previous study. RESULTS: In total, 828 (92.5%) TOS annual follow-up and HAQ and 810 (90.5%) PHQ-9 valid questionnaires were analysed. Participants' average age was 65.4 (Standard Deviation (SD): 13.4), 521 (62.9%) were women, 725 (87.6%) reported having at least other chronic disease and 789 (95.3%) an additional TOS-related health problem. Average scores were 0.91 (SD: 0.83) for HAQ, 35.8 (SD: 10.1) for PCS and 37.8 (SD: 11.6) for MCS. Overall, 467 (57.7%) participants had moderate/severe depression (PHQ-9 ≥ 10), but only 229 (49.6%) of them reported having a depression diagnosis. Correlation between questionnaires was very strong for HAQ and physical function SF-36v2 dimension and moderate/fair for the rest of combinations. CONCLUSIONS: TOS cohort presented low/very low health status measured with SF-36v2, moderate difficulties in performing daily activities according to HAQ, and a high prevalence of major depression measured with PHQ-9. High proportion of undiagnosed depression was detected, proving PHQ-9 useful in terms of detecting and promoting depression diagnosis in the cohort.
Authors: I Abaitua Borda; R M Philen; M Posada de la Paz; A Gómez de la Cámara; M Díez Ruiz-Navarro; O Giménez Ribota; J Alvargonzález Soldevilla; B Terracini; S Severiano Peña; C Fuentes Leal; E M Kilbourne Journal: Int J Epidemiol Date: 1998-12 Impact factor: 7.196
Authors: A Gómez de la Cámara; M Posada de la Paz; I Abaitua Borda; M T Barainca Oyagüe; V Abraira Santos; M D Ruiz-Navarro; B Terracini Journal: J Clin Epidemiol Date: 1998-10 Impact factor: 6.437
Authors: I Abaitua Borda; E M Kilbourne; M Posada de la Paz; M Diez Ruiz-Navarro; R Gabriel Sanchez; H Falk Journal: Int J Epidemiol Date: 1993-12 Impact factor: 7.196
Authors: A Alonso-Ruiz; A C Zea-Mendoza; J M Salazar-Vallinas; A Rocamora-Ripoll; J Beltrán-Gutiérrez Journal: Semin Arthritis Rheum Date: 1986-02 Impact factor: 5.532