Literature DB >> 35649473

WNK1 kinase signaling in metastasis and angiogenesis.

Chia-Ying Hou1, Chung-Yung Ma2, Chiou-Hwa Yuh3.   

Abstract

With-no-lysine kinases (WNKs) are a novel family of serine/threonine protein kinases participating in ion homeostasis via the WNK-OSR1/SPAK-NKCC cascade. Recent studies of WNK1 have revealed that its related signaling pathways mediated tumor-induced angiogenesis and carcinogenesis and uncovered novel roles of WNK1 in endothelial cell migration and proliferation, tumor cell proliferation, and metastasis. Herein, we review the functions of WNK1 in cancer metastasis and angiogenesis and propose WNK1 targeting as an anti-cancer strategy.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Angiogenesis; Ion homeostasis; Metastasis; Signaling pathways; WNK-OSR1/SPAK-NKCC

Mesh：

Substances：

Year:  2022        PMID： 35649473     DOI： 10.1016/j.cellsig.2022.110371

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.850


  2 in total

1.  Magnesium Ions Promote In Vitro Rat Bone Marrow Stromal Cell Angiogenesis Through Notch Signaling.

Authors:  Haotian Qin; Jian Weng; Bo Zhou; Weifei Zhang; Guoqing Li; Yingqi Chen; Tiantian Qi; Yuanchao Zhu; Fei Yu; Hui Zeng
Journal:  Biol Trace Elem Res       Date:  2022-07-23       Impact factor: 4.081

2.  Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A.

Authors:  Vidhya A Nair; Lara J Bou Malhab; Wael M Abdel-Rahman
Journal:  Int J Mol Sci       Date:  2022-10-01       Impact factor: 6.208
  2 in total

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