Literature DB >> 356490

[Clinical studies on the effect of pregnancy and labor on the pharmacokinetics of ampicillin].

R Voigt, S Schröder, P Meinhold, I Zenner, H Nöschel.   

Abstract

After giving 5 g Ampicillin intravenously to a total of 33 women (gravidae during the VIII. month pregnancy, women in labor and health controll persons) the serum levels of the mothers were analysed according to the pharmacokinetic parameter half-life of elimination.--Our results show that only the delivery cause significant differences of the kinetic of ampicillin.--Our results are discussed with the data given by literature.

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Year:  1978        PMID: 356490

Source DB:  PubMed          Journal:  Zentralbl Gynakol        ISSN: 0044-4197


  5 in total

Review 1.  Pharmacokinetic changes during pregnancy and their clinical relevance.

Authors:  R Loebstein; A Lalkin; G Koren
Journal:  Clin Pharmacokinet       Date:  1997-11       Impact factor: 6.447

Review 2.  Pharmacokinetics of antibiotics in pregnancy and labour.

Authors:  A Philipson
Journal:  Clin Pharmacokinet       Date:  1979 Jul-Aug       Impact factor: 6.447

3.  The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women.

Authors:  Anouk E Muller; P Joep Dörr; Johan W Mouton; Joost De Jongh; Paul M Oostvogel; Eric A P Steegers; Rob A Voskuyl; Meindert Danhof
Journal:  Br J Clin Pharmacol       Date:  2008-12       Impact factor: 4.335

Review 4.  Review of beta-lactam antibiotics in pregnancy. The need for adjustment of dosage schedules.

Authors:  A Heikkilä; R Erkkola
Journal:  Clin Pharmacokinet       Date:  1994-07       Impact factor: 6.447

Review 5.  Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review.

Authors:  Gali Pariente; Tom Leibson; Alexandra Carls; Thomasin Adams-Webber; Shinya Ito; Gideon Koren
Journal:  PLoS Med       Date:  2016-11-01       Impact factor: 11.069

  5 in total

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