[Plastic changes in the spontaneous activity of pond snail neurons during rhythmic and associated intracellular electrostimulation].

In experiments on spontaneously active neurones of the isolated CNS of pond snail, under contingent stimulation with selective auto-reinforcement of interpulse intervals longer than their mean background value, 70 per cent of neurones were capable of adaptive rearrangements of the initial firing frequency, leading to frequency minimization or maximization of influences applied to them. After control rhythmic stimulation, usually no substantial changes of spontaneous activity were observed. The detected phenomena of initial transformation of the spontaneous impulse activity are considered as a cellular analogue of the instrumental conditioned reflex.