Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Detection of adenovirus nucleic acid sequences in human tonsils in the absence of infectious virus.

Literature DB >> 3564677

Detection of adenovirus nucleic acid sequences in human tonsils in the absence of infectious virus.

Abstract

Human tonsillar and adenoid tissues from surgical specimens and cell cultures established therefrom were screened for adenovirus type 2 (Ad2) sequences by in situ hybridization. For labeling we have utilized biotinylated DNA probes. We report detection of adenoviral sequences after hybridization with adenovirus type 2 DNA probes in tissues as well as in cell cultures from specimens without any signs of infectious virus even after long-term cultivation. In the infected tonsils only some of the cells appear to carry viral sequences. In conclusion, truly latent adenovirus infections in man seem to occur.

Entities: Disease Species

Mesh：

Substances：
DNA, Viral

Year: 1987 PMID： 3564677 DOI： 10.1016/0168-1702(87)90060-8

Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303

Keyword Cloud
Cited

26 in total

1. Modeling adenovirus latency in human lymphocyte cell lines.

Authors: Yange Zhang; Wen Huang; David A Ornelles; Linda R Gooding
Journal: J Virol Date: 2010-06-23 Impact factor: 5.103

2. Effect of CD4 gene expression on adenovirus replication.

Authors: J Hotta; L Shi; H S Ginsberg
Journal: J Virol Date: 1994-11 Impact factor: 5.103

3. Study of vertical transmission of fowl adenoviruses.

Authors: Helena Grgić; Cynthia Philippe; Davor Ojkić; Eva Nagy
Journal: Can J Vet Res Date: 2006-07 Impact factor: 1.310

4. Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA.

Authors: Yuki Furuse; David A Ornelles; Bryan R Cullen
Journal: Virology Date: 2013-09-26 Impact factor: 3.616

5. The adenovirus E3 RID complex protects some cultured human T and B lymphocytes from Fas-induced apoptosis.

Authors: Adrienne L McNees; C T Garnett; Linda R Gooding
Journal: J Virol Date: 2002-10 Impact factor: 5.103

6. A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication.

Authors: F W Weindler; R Heilbronn
Journal: J Virol Date: 1991-05 Impact factor: 5.103

Detection of adenovirus nucleic acid sequences in human tonsils in the absence of infectious virus.

1. Modeling adenovirus latency in human lymphocyte cell lines.

2. Effect of CD4 gene expression on adenovirus replication.

3. Study of vertical transmission of fowl adenoviruses.

4. Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA.

5. The adenovirus E3 RID complex protects some cultured human T and B lymphocytes from Fas-induced apoptosis.

6. A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication.

7. Latent species C adenoviruses in human tonsil tissues.

8. Histone Deacetylase Inhibitors Promote Latent Adenovirus Reactivation from Tonsillectomy Specimens.

9. Adenovirus pulmonary infections identified by PCR and in situ hybridisation in bone marrow transplant recipients.

10. Role of genetic susceptibility to latent adenoviral infection and decreased lung function.