| Literature DB >> 35640879 |
Christopher A Darlow, William Hope.
Abstract
Entities:
Year: 2022 PMID: 35640879 PMCID: PMC9244209 DOI: 10.1093/jac/dkac153
Source DB: PubMed Journal: J Antimicrob Chemother ISSN: 0305-7453 Impact factor: 5.758
Median, mean and variance parameter values from the final PopPK model
| Parameter | Median (95% credibility interval) | Mean | SD |
|---|---|---|---|
| ClStd (L/h/70 kg) | 24.059 (21.667–30.842) | 23.759 | 10.483 |
| VStd (L/70 kg) | 19.595 (18.23–21.585) | 22.499 | 13.361 |
| KCP (h−1) | 2.770 (1.709–4.696) | 5.890 | 6.516 |
| KPC (h−1) | 7.007 (2.438–13.201) | 11.443 | 10.764 |
| A | 0.350 (0.299–0.458) | 0.400 | 0.233 |
| B | 0.744 (0.695–0.790) | 0.693 | 0.260 |
ClStd and VStd are estimated standardized clearances and volume of the central compartment values, adjusted for weight±age. KCP and KPC are kinetic constants determining movement between the central and peripheral compartments and vice versa. A and B are the estimated exponents for age and weight for clearance.