Literature DB >> 3564073

The use of N-acetylcysteine long after an acetaminophen overdose in mice.

P W Banda, B D Quart.   

Abstract

N-Acetylcysteine (NAC), given to mice 5 h after an LD50 dose of acetaminophen, decreased 24-h survival to 33%. The reduction in survival observed for late NAC is significantly lower than the survival observed for the LD50 dose alone (53%), and is in sharp contrast to the 100% survival reported for the early use of NAC.

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Year:  1987        PMID： 3564073     DOI： 10.1016/0378-4274(87)90045-2

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  3 in total

1.  Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.

Authors:  R Keays; P M Harrison; J A Wendon; A Forbes; C Gove; G J Alexander; R Williams
Journal:  BMJ       Date:  1991-10-26

2.  Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters.

Authors:  Pranee Sriraj; Thidarut Boonmars; Ratchadawan Aukkanimart; Atchara Artchayasawat; Glenn N Borlace; Panaratana Ratanasuwan; Benjamabhorn Pumhirunroj
Journal:  Asian Pac J Cancer Prev       Date:  2021-12-01

3.  Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair.

Authors:  Wenting Yang; Yuandong Tao; Yan Wu; Xinyuan Zhao; Weijie Ye; Dianyuan Zhao; Ling Fu; Caiping Tian; Jing Yang; Fuchu He; Li Tang
Journal:  Nat Commun       Date:  2019-03-06       Impact factor: 14.919
  3 in total

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