Norbert Heine1, Andreas Eigenberger2,3, Vanessa Brebant2, Sally Kempa2, Stephan Seitz4, Lukas Prantl2, Britta Kuehlmann2. 1. Aesthetic, Hand and Reconstructive Surgery, University Center for Plastic, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. nheine@csj.de. 2. Aesthetic, Hand and Reconstructive Surgery, University Center for Plastic, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. 3. Faculty of Mechanical Engineering, Ostbayerische Technische Hochschule Regensburg (OTH Regensburg), Regensburg, Germany. 4. Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University of Regensburg, Regensburg, Germany.
Abstract
PURPOSE: Lipofilling has been established as a standard technique for contour enhancement following breast reconstruction. However, there is a paucity in current literature regarding the use of this technique for complete reconstruction of the female breast as an alternative to conventional techniques, such as expander or flap-based procedures. In particular, the influence of pre-operative irradiation for successful reconstruction has rarely been examined in published studies. Here, the authors describe their experience with successful fat injection in pre-radiated breasts in comparison with non-pre-radiated patients. METHODS: In this retrospective study, we examined a total of 95 lipofilling treatments on 26 patients (28 breasts). All of them experienced mastectomy following breast cancer; local breast defects after partial resection of the gland were not included in this study. In total, 47 lipofilling procedures in 12 non-irradiated patients (14 breasts) and 48 procedures in 14 irradiated women (also 14 breasts) were performed. Per session, approximately 297 ± 112 cc of adipose tissue was grafted in group A (no radiotherapy) and approximately 259 ± 93 cc was grafted in group B (radiotherapy). RESULTS: Among the group of women without pre-operative radiation, 71% of breast reconstructions limited to lipofilling only showed constant engraftment of fat tissue with a successful reconstructive result, whereas only 21% of the patients with pre-radiated breasts showed complete reconstruction of the breast with a permanent fat in-growth. CONCLUSION: Preoperative radiotherapy significantly impedes successful completion of breast reconstructions planned only by autologous fat transfer. Patients should be selected individually and carefully for complete breast reconstruction using lipofilling only.
PURPOSE: Lipofilling has been established as a standard technique for contour enhancement following breast reconstruction. However, there is a paucity in current literature regarding the use of this technique for complete reconstruction of the female breast as an alternative to conventional techniques, such as expander or flap-based procedures. In particular, the influence of pre-operative irradiation for successful reconstruction has rarely been examined in published studies. Here, the authors describe their experience with successful fat injection in pre-radiated breasts in comparison with non-pre-radiated patients. METHODS: In this retrospective study, we examined a total of 95 lipofilling treatments on 26 patients (28 breasts). All of them experienced mastectomy following breast cancer; local breast defects after partial resection of the gland were not included in this study. In total, 47 lipofilling procedures in 12 non-irradiated patients (14 breasts) and 48 procedures in 14 irradiated women (also 14 breasts) were performed. Per session, approximately 297 ± 112 cc of adipose tissue was grafted in group A (no radiotherapy) and approximately 259 ± 93 cc was grafted in group B (radiotherapy). RESULTS: Among the group of women without pre-operative radiation, 71% of breast reconstructions limited to lipofilling only showed constant engraftment of fat tissue with a successful reconstructive result, whereas only 21% of the patients with pre-radiated breasts showed complete reconstruction of the breast with a permanent fat in-growth. CONCLUSION: Preoperative radiotherapy significantly impedes successful completion of breast reconstructions planned only by autologous fat transfer. Patients should be selected individually and carefully for complete breast reconstruction using lipofilling only.
Authors: L Prantl; H O Rennekampff; R E Giunta; Y Harder; D von Heimburg; N Heine; C Herold; U Kneser; F Lampert; H G Machens; U Mirastschijski; D Müller; N Pallua; T Schantz; A Schönborn; K Ueberreiter; C H Witzel; G Bull; D Rezek; G Sattler; P M Vogt; R E Horch Journal: Handchir Mikrochir Plast Chir Date: 2016-11-10 Impact factor: 1.018
Authors: Bindu V Manyam; Chirag Shah; Neil M Woody; Chandana A Reddy; Michael A Weller; Aditya Juloori; Mihir Naik; Stephanie Valente; Stephen Grobmyer; Paul Durand; Risal Djohan; Rahul D Tendulkar Journal: Breast J Date: 2019-07-01 Impact factor: 2.431
Authors: J Y Petit; M Rietjens; E Botteri; N Rotmensz; F Bertolini; G Curigliano; P Rey; C Garusi; F De Lorenzi; S Martella; A Manconi; B Barbieri; P Veronesi; M Intra; T Brambullo; A Gottardi; M Sommario; G Lomeo; M Iera; V Giovinazzo; V Lohsiriwat Journal: Ann Oncol Date: 2013-02-07 Impact factor: 32.976
Authors: Rachel L O'Connell; Rosa Di Micco; Komel Khabra; Anna M Kirby; Paul A Harris; Stuart E James; Kieran Power; Kelvin W D Ramsey; Jennifer E Rusby Journal: Plast Reconstr Surg Date: 2018-09 Impact factor: 4.730