Literature DB >> 356311

Tranexamic acid in the preoperative management of ruptured intracranial aneurysms.

H Fodstad, B Liliequist, M Schannong, C A Thulin.   

Abstract

A randomized, controlled clinical trial was carried out to study the effect of tranexamic acid (AMCA, trans-AMCHA) in prevention of early rebleeding after proven rupture of an intracranial aneurysm. The series comprises 46 patients admitted to the hospital within three days after the first bleeding. Twenty-three were treated with tranexamic acid and 23 were controls. Nine patients in the control group and one in the group treated with tranexamic acid had confirmed rebleeding. The incidence of vasospasm, cerebral ischemia and hydrocephalus as well as mortality and morbidity is discussed.

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Year:  1978        PMID: 356311

Source DB:  PubMed          Journal:  Surg Neurol        ISSN: 0090-3019


  23 in total

Review 1.  Antifibrinolytic agents in subarachnoid haemorrhage.

Authors:  K W Lindsay
Journal:  J Neurol       Date:  1987-01       Impact factor: 4.849

2.  Antifibrinolytics in aneurysmal subarachnoid haemorrhage. A retrospective comparison of two different forms of antifibrinolytic therapy.

Authors:  A Spallone
Journal:  Acta Neurochir (Wien)       Date:  1982       Impact factor: 2.216

3.  Antifibrinolytic agents for ruptured intracranial aneurysms.

Authors:  R S Maurice-Williams
Journal:  Br Med J       Date:  1978-09-16

4.  Letter to the editors of acta neurochirurgica. Management of patients with subarachnoid haemorrhage with tranexamic acid.

Authors:  H Fodstad; C A Thulin
Journal:  Acta Neurochir (Wien)       Date:  1980       Impact factor: 2.216

5.  Fibrinolytic activity after subarachnoid haemorrhage and the effect of tranexamic acid.

Authors:  S A Tsementzis; W P Honan; S Nightingale; E R Hitchcock; C H Meyer
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

Review 6.  Antifibrinolytic treatment in subarachnoid haemorrhage: present state.

Authors:  H Fodstad
Journal:  Acta Neurochir (Wien)       Date:  1982       Impact factor: 2.216

Review 7.  Antifibrinolytic therapy to prevent early rebleeding after subarachnoid hemorrhage.

Authors:  Mark Chwajol; Robert M Starke; Grace H Kim; Stephan A Mayer; E Sander Connolly
Journal:  Neurocrit Care       Date:  2008       Impact factor: 3.210

8.  Rebleeding, ischaemia and hydrocephalus following anti-fibrinolytic treatment for ruptured cerebral aneurysms: a retrospective clinical study.

Authors:  G Pinna; A Pasqualin; C Vivenza; R Da Pian
Journal:  Acta Neurochir (Wien)       Date:  1988       Impact factor: 2.216

9.  Tranexamic acid (AMCA) in aneurysmal subarachnoid haemorrhage.

Authors:  H Fodstad
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1980

10.  Monitoring fibrinolytic activity in the cerebrospinal fluid after aneurysmal subarachnoid haemorrhage: a guide to the risk of rebleeding?

Authors:  R S Maurice-Williams; Y B Gordon; A Sykes
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-02       Impact factor: 10.154

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