| Literature DB >> 35626916 |
Robert E Shaw1, Steven J Staffa2, Viviane G Nasr2, Cynthia Tung2.
Abstract
BACKGROUND: Healthcare providers encounter varying languages every day in patient care. The goal of this study was to examine whether a difference exists in pain scoring and treatment amongst pediatric patients whose families' primary language was not English. We hypothesized that patients of both Arabic-speaking (AS) and Spanish-speaking (SS) backgrounds received higher pain scores and higher daily opioid equivalents (OEs) postoperatively compared to English-speaking (ES) patients.Entities:
Keywords: acute pain; anesthesia; disparities; surgery
Year: 2022 PMID: 35626916 PMCID: PMC9139688 DOI: 10.3390/children9050739
Source DB: PubMed Journal: Children (Basel) ISSN: 2227-9067
Figure 1Number of patients with exclusion criteria and propensity matching applied.
Opioid Equivalents and Pain Scores by Language Prior to Propensity Score Matching.
| Outcome | English Group ( | Arabic Group ( | Spanish Group ( | ||
|---|---|---|---|---|---|
| Opioid Equivalents per kg | |||||
| Intraoperative ( | 0.77 (0.29, 1.54) | 0.92 (0.25, 1.72) | 1.38 (0.54, 2.36) | 0.771 |
|
| 6 h ( | 0.15 (0.02, 0.35) | 0.17 (0.02, 0.34) | 0.23 (0.09, 0.49) | 0.881 |
|
| 12 h ( | 0.16 (0.01, 0.37) | 0.20 (0.04, 0.46) | 0.29 (0.10, 0.66) | 0.543 |
|
| 24 h ( | 0.27 (0.02, 0.72) | 0.36 (0.06, 0.87) | 0.38 (0.21, 1.09) | 0.197 |
|
| 36 h ( | 0.21 (0.01, 0.67) | 0.39 (0.03, 0.91) | 0.42 (0.11, 1.27) | 0.109 |
|
| 48 h postop. ( | 1.15 (0.12, 2.78) | 1.52 (0.43, 3.83) | 1.68 (0.75, 4.22) | 0.184 |
|
| Pain Scores | |||||
| First Pain Score ( | 0 (0, 4) | 0 (0, 0) | 0 (0, 5) |
| 0.523 |
| 6 h ( | 1 (0, 3) | 0 (0, 0) | 0.25 (0, 4.5) |
| 0.761 |
| 12 h ( | 1.5 (0, 3.5) | 0 (0, 1) | 1 (0, 3.5) |
| 0.99 |
| 24 h ( | 1.5 (0, 3) | 0 (0, 2) | 1 (0, 3) | 0.197 | 0.808 |
| 36 h ( | 1 (0, 3) | 0.5 (0, 2) | 0 (0, 2) | 0.224 | 0.16 |
| 48 h ( | 0 (0, 2) | 0 (0, 1.5) | 0 (0, 2) | 0.336 | 0.493 |
Data are presented as median (interquartile range). Sample sizes for patients with non-missing pain scores data (n) in each group are indicated. p values were calculated using the Wilcoxon rank sum test. * Statistically significant. The bold for p-values.
Patient Characteristics Before and After Propensity Score Matching Between English- and Arabic-Speaking Patients.
| Before Propensity Score Matching | ||||
|---|---|---|---|---|
| Variable | English Group ( | Arabic Group ( | SMD | |
| Age (years) | 0.89 (0.28, 3.05) | 1.32 (0.61, 4.11) |
| 0.105 |
| Weight (kg) | 7.89 (4.5, 14.1) | 8.04 (5.39, 16.2) | 0.387 | 0.016 |
| Sex | ||||
| Female | 208 (38.7%) | 19 (42.2%) | 0.645 | 0.071 |
| Male | 329 (61.3%) | 26 (57.8%) | ||
| Surgical Procedures—CPT Codes | ||||
| 31750 | 37 (6.9%) | 2 (4.4%) | 0.759 | 0.105 |
| 31760 | 367 (68.3%) | 30 (66.7%) | 0.817 | 0.036 |
| 33800 | 244 (45.4%) | 22 (48.9%) | 0.655 | 0.069 |
| 43305 | 16 (3%) | 4 (8.9%) | 0.060 | 0.250 |
| 43312 | 91 (17%) | 11 (24.4%) | 0.204 | 0.185 |
| 43313 | 127 (23.7%) | 18 (40%) |
| 0.354 |
| 43314 | 97 (18.1%) | 5 (11.1%) | 0.309 | 0.197 |
| Encounter | ||||
| First | 419 (78%) | 34 (75.6%) | 0.702 | 0.058 |
| Second | 119 (22%) | 11 (24.4%) | ||
| Developmental Delay | 163 (30.4%) | 27 (60%) |
| 0.62 |
| History of Chronic Pain | 3 (0.6%) | 1 (2.2%) | 0.276 | 0.141 |
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| Age (years) | 0.96 (0.36, 2.77) | 1.32 (0.66, 4.25) | 0.050 | 0.051 |
| Weight (kg) | 8.39 (5.3, 13) | 8.6 (5.39, 16.5) | 0.336 | 0.059 |
| Sex | ||||
| Female | 80 (41%) | 18 (46.2%) | 0.553 | 0.103 |
| Male | 115 (59%) | 21 (53.8%) | ||
| Surgical Procedures—CPT Codes | ||||
| 31750 | 8 (4.1%) | 2 (5.1%) | 0.675 | 0.048 |
| 31760 | 139 (71.3%) | 25 (64.1%) | 0.371 | 0.153 |
| 33800 | 93 (47.7%) | 18 (46.2%) | 0.861 | 0.031 |
| 43305 | 8 (4.1%) | 3 (7.7%) | 0.399 | 0.151 |
| 43312 | 48 (24.6%) | 8 (20.5%) | 0.684 | 0.098 |
| 43313 | 64 (32.8%) | 14 (35.9%) | 0.713 | 0.064 |
| 43314 | 25 (12.8%) | 5 (12.8%) | 0.999 | 0 |
| Encounter | ||||
| First | 145 (74.4%) | 39 (74.4%) | 0.999 | 0 |
| Second | 50 (25.6%) | 10 (25.6%) | ||
| Developmental Delay | 104 (53.3%) | 21 (53.9%) | 0.999 | 0.01 |
| History of Chronic Pain | 3 (1.5%) | 1 (2.6%) | 0.520 | 0.072 |
Continuous data are presented as median (interquartile range), and categorical data are presented as n (%) within each group on the encounter level. p values were calculated using the Wilcoxon rank sum test, the Chi-square test, or Fisher’s exact test, as appropriate. A standardized mean difference value less than 0.2 is considered as reflecting good balance between the two groups. * Statistically significant. The bold for p-values. SMD, absolute standardized mean difference.
Patient Characteristics Before and After Propensity Score Matching Between English- and Spanish-Speaking Patients.
| Before Propensity Score Matching | ||||
|---|---|---|---|---|
| Variable | English Group ( | Spanish Group ( | SMD | |
| Age (years) | 0.89 (0.28, 3.05) | 0.70 (0.29, 1.51) | 0.477 | 0.055 |
| Weight (kg) | 7.89 (4.5, 14.1) | 6.2 (5.26, 10.65) | 0.457 | 0.287 |
| Sex | ||||
| Female | 208 (38.7%) | 13 (46.4%) | 0.432 | 0.155 |
| Male | 329 (61.3%) | 15 (53.6%) | ||
| Surgical Procedures—CPT Codes | ||||
| 31750 | 37 (6.9%) | 3 (10.7%) | 0.439 | 0.134 |
| 31760 | 367 (68.3%) | 18 (64.3%) | 0.679 | 0.085 |
| 33800 | 244 (45.4%) | 14 (50%) | 0.637 | 0.091 |
| 43305 | 16 (3%) | 2 (7.1%) | 0.223 | 0.188 |
| 43312 | 91 (17%) | 6 (21.4%) | 0.605 | 0.113 |
| 43313 | 127 (23.7%) | 6 (21.4%) | 0.999 | 0.053 |
| 43314 | 97 (18.1%) | 5 (17.9%) | 0.999 | 0.005 |
| Encounter | ||||
| First | 419 (78%) | 20 (71.4%) | 0.484 | 0.151 |
| Second | 119 (22%) | 8 (28.6%) | ||
| Developmental Delay | 162 (30.2%) | 12 (42.9%) | 0.156 | 0.263 |
| History of Chronic Pain | 3 (0.6%) | 0 (0%) | 0.999 | 0.106 |
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| Age (years) | 0.69 (0.23, 1.83) | 0.69 (0.27, 1.39) | 0.821 | 0.013 |
| Weight (kg) | 7.1 (4.4, 11.1) | 6.2 (5.3, 10.4) | 0.795 | 0.033 |
| Sex | ||||
| Female | 50 (37%) | 12 (44.4%) | 0.47 | 0.149 |
| Male | 85 (63%) | 15 (55.6%) | ||
| Surgical Procedures—CPT Codes | ||||
| 31750 | 12 (8.9%) | 2 (7.4%) | 0.999 | 0.054 |
| 31760 | 85 (63%) | 18 (66.7%) | 0.828 | 0.077 |
| 33800 | 66 (48.9%) | 14 (51.9%) | 0.835 | 0.059 |
| 43305 | 4 (3%) | 1 (3.7%) | 0.999 | 0.041 |
| 43312 | 27 (20%) | 6 (22.2%) | 0.796 | 0.054 |
| 43313 | 35 (25.9%) | 6 (22.2%) | 0.811 | 0.086 |
| 43314 | 25 (18.5%) | 5 (18.5%) | 0.999 | 0 |
| Encounter | ||||
| First | 96 (71.1%) | 19 (70.4%) | 0.999 | 0.016 |
| Second | 39 (28.9%) | 8 (29.6%) | ||
| Developmental Delay | 53 (39.3%) | 12 (44.4%) | 0.67 | 0.11 |
| History of Chronic Pain | 0 (0%) | 0 (0%) | 0.999 | 0 |
Continuous data are presented as median (interquartile range), and categorical data are presented as n (%) within each group on the encounter level. p values were calculated using the Wilcoxon rank sum test, the Chi-square test, or Fisher’s exact test, as appropriate. A standardized mean difference value less than 0.2 is considered as reflecting good balance between the two groups. SMD, absolute standardized mean difference.
Figure 2Opioid equivalents and pain score comparisons amongst propensity matched language groups. (A): Opioid equivalent per kg vs. time in matched English and Arabic groups; (B): Opioid equivalent per kg vs. time in matched English and Spanish groups; (C): Pain score vs. time in matched English and Arabic groups; (D): Pain score vs time in matched English and Spanish groups.
Figure 3Opioid equivalents and pain score comparisons amongst ES and AS patients with and without regional anesthesia. (A): Adjusted difference in opioid equivalents per kg vs. time in English vs. Arabic patients with regional anesthesia; (B): Adjusted difference in opioid equivalents per kg vs. time in English vs Arabic patients without regional anesthesia; (C): Adjusted difference in pain score vs. time in English vs. Arabic patients with regional anesthesia; (D): Adjusted difference pain score vs. time in English vs. Arabic patients without regional anesthesia.
Figure 4Opioid equivalents and pain score comparisons amongst ES and SS patients with and without regional anesthesia. (A): Adjusted difference in opioid equivalents per kg vs. time in English vs. Spanish patients with regional anesthesia; (B): Adjusted difference in opioid equivalents per kg vs. time in English vs. Spanish patients without regional anesthesia; (C): Adjusted difference in pain score vs. time in English vs. Spanish patients with regional anesthesia; (D): Adjusted difference pain score vs. time in English vs. Spanish patients without regional anesthesia.
Multivariable Median Regression Analysis of Outcomes Compared by Language Group.
| Outcome | Adjusted Difference in Medians—Arabic vs. English (95% CI) | Adjusted Difference in Medians—Spanish vs. English (95% CI) | ||
|---|---|---|---|---|
| Opioid Equivalents per kg | ||||
| Intraoperative | −0.04 (−0.35, 0.27) | 0.793 | 0.25 (−0.36, 0.86) | 0.421 |
| 6 h | 0.03 (−0.04, 0.09) | 0.461 | 0.03 (−0.08, 0.13) | 0.591 |
| 12 h | 0 (−0.1, 0.1) | 0.926 | 0.09 (−0.18, 0.35) | 0.51 |
| 24 h | 0.01 (−0.11, 0.13) | 0.848 | 0 (−0.16, 0.16) | 0.988 |
| 36 h | 0.01 (−0.11, 0.13) | 0.877 | 0.03 (−0.14, 0.21) | 0.71 |
| 48 h postop. | −0.01 (−0.54, 0.52) | 0.975 | 0.04 (−0.92, 1.01) | 0.929 |
| Pain Scores | ||||
| First Pain Score | −0.21 (−0.49, 0.08) | 0.153 | 0.01 (−0.29, 0.31) | 0.933 |
| 6 h | −0.55 (−1.15, 0.06) | 0.077 | −0.3 (−1.02, 0.43) | 0.425 |
| 12 h | −0.97 (−1.61, −0.33) |
| 0.1 (−1.52, 1.71) | 0.908 |
| 24 h | −1.38 (−2.02, −0.75) |
| −0.12 (−1.5, 1.25) | 0.859 |
| 36 h | −0.45 (−1.32, 0.42) | 0.308 | −0.69 (−1.4, 0.03) | 0.061 |
| 48 h | −0.06 (−0.4, 0.28) | 0.745 | −0.2 (−0.68, 0.28) | 0.417 |
Adjusted differences in medians with 95% confidence intervals and p values were calculated using multivariable median regression. Each model was adjusted for age, weight, sex, procedure, encounter number, developmental delay, history of chronic pain, regional use, opioid infusions, surgical duration, ventilation, and ICU admission. * Statistically significant. The bold for p-values. CI, confidence interval.