| Literature DB >> 35626485 |
Abstract
A novel yet simple extension of the symmetric logistic distribution is proposed by introducing a skewness parameter. It is shown how the three parameters of the ensuing skew logistic distribution may be estimated using maximum likelihood. The skew logistic distribution is then extended to the skew bi-logistic distribution to allow the modelling of multiple waves in epidemic time series data. The proposed skew-logistic model is validated on COVID-19 data from the UK, and is evaluated for goodness-of-fit against the logistic and normal distributions using the recently formulated empirical survival Jensen-Shannon divergence (ESJS) and the Kolmogorov-Smirnov two-sample test statistic (KS2). We employ 95% bootstrap confidence intervals to assess the improvement in goodness-of-fit of the skew logistic distribution over the other distributions. The obtained confidence intervals for the ESJS are narrower than those for the KS2 on using this dataset, implying that the ESJS is more powerful than the KS2.Entities:
Keywords: COVID-19 data; Kolmogorov–Smirnov two-sample test; bi-logistic growth; empirical survival Jensen–Shannon divergence; epidemic waves; skew logistic distribution
Year: 2022 PMID: 35626485 PMCID: PMC9140682 DOI: 10.3390/e24050600
Source DB: PubMed Journal: Entropy (Basel) ISSN: 1099-4300 Impact factor: 2.738
Figure 1Reported daily COVID-19 deaths from 30 January 2020 to 30 July 2021 and their minima labelled ‘*’, resulting in four distinct waves; a moving average with a centred sliding window of 7 days was applied to the raw data.
Parameters from maximum likelihood fits of the skew logistic distribution to the four waves, and the day of the local minimum (End), which is the end point of the wave.
| Fitted Parameters for the Skew Logistic Distribution | ||||
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| 1 | 0.2150 | 3.5137 | 3.8443 | 71 |
| 2 | 1.0741 | 196.5157 | 14.4323 | 239 |
| 3 | 0.2297 | 243.0709 | 4.5882 | 334 |
| 4 | 1.7306 | 502.2758 | 7.0195 | 532 |
Figure 2Histograms for the four waves of COVID-19 deaths from 30 January 2020 to 30 July 2021, each overlaid with the curve of the maximum likelihood fit of the skew logistic distribution to the data.
Pearson’s moment and median skewness coefficients for the four waves, and the correlation between and these coefficients.
| Skewness | |||
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| 1 | 0.7850 | 0.9314 | 0.2939 |
| 2 | −0.0741 | −0.7758 | −0.0797 |
| 3 | 0.7703 | 0.9265 | 0.1939 |
| 4 | −0.7306 | −1.5555 | −0.2413 |
| Correlation | 0.9931 | 0.9826 | |
values for the skew logistic (SL), logistic (Logit) and normal (Norm) distributions, and the improvement percentage of the skew logistic over the logistic (SL-Logit) and normal (SL-Norm) distributions, respectively.
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| 1 | 0.0419 | 0.0583 | 28.25% | 0.0649 | 35.54% |
| 2 | 0.0392 | 0.0448 | 12.52% | 0.0613 | 36.17% |
| 3 | 0.0316 | 0.0387 | 18.38% | 0.0423 | 25.38% |
| 4 | 0.0237 | 0.0927 | 74.47% | 0.0939 | 74.79% |
values for the skew logistic (SL), logistic (Logit) and normal (Norm) distributions, and the improvement percentage of the skew logistic over the logistic (SL-Logit) and normal (SL-Norm) distributions, respectively.
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| 1 | 0.0621 | 0.1245 | 50.14% | 0.1280 | 51.50% |
| 2 | 0.0357 | 0.0391 | 8.57% | 0.0420 | 15.01% |
| 3 | 0.0571 | 0.0930 | 38.66% | 0.0854 | 33.18% |
| 4 | 0.0098 | 0.0817 | 87.98% | 0.1046 | 90.61% |
Results from the percentile method for the confidence interval of the difference of the between the logistic (Logit) and skew logistic (SL), and between the normal (Norm) and skew logistic (SL) distributions, respectively; Diff, LB, UB, CI, Mean and STD stand for difference, lower bound, upper bound, confidence interval, mean of samples and standard deviation of samples, respectively.
| Percentile Confidence Intervals for | |||||
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| 1/SL-Logit | 0.0093 | 0.0317 | 0.0224 | 0.0211 | 0.0063 |
| 1/SL-Norm | 0.0170 | 0.0382 | 0.0212 | 0.0278 | 0.0063 |
| 2/SL-Logit |
| 0.0066 | 0.0076 | 0.0034 | 0.0049 |
| 2/SL-Norm | 0.0154 | 0.0232 | 0.0078 | 0.0201 | 0.0051 |
| 3/SL-Logit |
| 0.0112 | 0.0140 | 0.0083 | 0.0022 |
| 3/SL-Norm | 0.0021 | 0.0149 | 0.0128 | 0.0120 | 0.0022 |
| 4/SL-Logit | 0.0549 | 0.0810 | 0.0261 | 0.0714 | 0.0068 |
| 4/SL-Norm | 0.0560 | 0.0821 | 0.0261 | 0.0722 | 0.0070 |
Results from the percentile method for the confidence interval of the difference of the between the logistic (Logit) and skew logistic (SL), and between the normal (Norm) and skew logistic (SL) distributions, respectively; Diff, LB, UB, CI, Mean and STD stand for difference, lower bound, upper bound, confidence interval, mean of samples and standard deviation of samples, respectively.
| Percentile Confidence Intervals for | |||||
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| 1/SL-Logit | 0.0438 | 0.0760 | 0.0322 | 0.0621 | 0.0073 |
| 1/SL-Norm | 0.0411 | 0.0821 | 0.0410 | 0.0684 | 0.0078 |
| 2/SL-Logit | 0.0003 | 0.0047 | 0.0044 | 0.0033 | 0.0009 |
| 2/SL-Norm | 0.0007 | 0.0092 | 0.0085 | 0.0065 | 0.0017 |
| 3/SL-Logit |
| 0.0441 | 0.0514 | 0.0343 | 0.0082 |
| 3/SL-Norm |
| 0.0365 | 0.0507 | 0.0267 | 0.0080 |
| 4/SL-Logit | 0.0474 | 0.0728 | 0.0254 | 0.0680 | 0.0046 |
| 4/SL-Norm | 0.0710 | 0.0962 | 0.0252 | 0.0905 | 0.0048 |
Results from the BCa method for the confidence interval of the difference of the between the logistic (Logit) and skew logistic (SL), and between the normal (Norm) and skew logistic (SL) distributions, respectively; Diff, LB, UB, CI, Mean and STD stand for difference, lower bound, upper bound, confidence interval, mean of samples and standard deviation of samples, respectively.
| BCa Confidence Intervals for | |||||
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| 1/SL-Logit | 0.0087 | 0.0260 | 0.0173 | 0.0210 | 0.0062 |
| 1/SL-Norm | 0.0165 | 0.0333 | 0.0168 | 0.0275 | 0.0063 |
| 2/SL-Logit |
| 0.0258 | 0.0267 | 0.0036 | 0.0053 |
| 2/SL-Norm | 0.0153 | 0.0425 | 0.0272 | 0.0201 | 0.0050 |
| 3/SL-Logit |
| 0.0095 | 0.0119 | 0.0084 | 0.0023 |
| 3/SL-Norm |
| 0.0135 | 0.0162 | 0.0119 | 0.0024 |
| 4/SL-Logit | 0.0308 | 0.0703 | 0.0395 | 0.0708 | 0.0074 |
| 4/SL-Norm | 0.0554 | 0.0713 | 0.0159 | 0.0726 | 0.0069 |
Results from the BCa method for the confidence interval of the difference of the between the logistic (Logit) and skew logistic (SL), and between the normal (Norm) and skew logistic (SL) distributions, respectively; Diff, LB, UB, CI, Mean and STD stand for difference, lower bound, upper bound, confidence interval, mean of samples and standard deviation of samples, respectively.
| BCa Confidence Intervals for | |||||
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| 1/SL-Logit | 0.0428 | 0.0801 | 0.0373 | 0.0624 | 0.0074 |
| 1/SL-Norm | 0.0444 | 0.0777 | 0.0333 | 0.0683 | 0.0078 |
| 2/SL-Logit | 0.0005 | 0.0047 | 0.0042 | 0.0033 | 0.0008 |
| 2/SL-Norm | 0.0001 | 0.0089 | 0.0088 | 0.0064 | 0.0017 |
| 3/SL-Logit | 0.0013 | 0.0445 | 0.0432 | 0.0346 | 0.0077 |
| 3/SL-Norm |
| 0.0368 | 0.0479 | 0.0263 | 0.0082 |
| 4/SL-Logit | 0.0491 | 0.0739 | 0.0248 | 0.0676 | 0.0047 |
| 4/SL-Norm | 0.0685 | 0.0985 | 0.0300 | 0.0908 | 0.0046 |
Mean and standard deviation (STD) statistics for the confidence interval (CI) widths using the percentile (P) and BCa methods.
| Summary Statistics for the CI Widths | ||||
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| Mean | 0.0172 | 0.0298 | 0.0214 | 0.0287 |
| STD | 0.0077 | 0.0176 | 0.0091 | 0.0155 |