| Literature DB >> 35622261 |
V V Revin1, L A Balykova1, O A Radaeva1, V V Shchapov1,2, E S Revina1, S I Pinyaev1, Yu A Kostina1, E D Kozlov3.
Abstract
Morphological and functional characteristics of erythrocytes, hemoglobin, and erythropoietin level in the venous blood were evaluated by laser interference microscopy, Raman spectroscopy with a short-focus extreme aperture lens monochromator, and by ELISA, respectively, in 30 patients with verified moderate COVID-19 at the time of hospitalization and 30 healthy volunteers. The patients whose course of COVID-19 has worsened to critical by day 5 had already had lower (p<0.001) indicators at the time of hospitalization such as the area and thickness of erythrocytes, the hemoglobin distribution and packing density, hemoglobin conformation index (I1355/I1550)/(I1375/I1580) reflecting its oxygen affinity, and blood erythropoietin content. Our findings suggest that these characteristics of erythrocytes, hemoglobin, and erythropoietin can serve as potential predictors of COVID-19 aggravation in hospitalized patients.Entities:
Keywords: COVID-19; erythrocytes; erythropoietin; hemoglobin; worsening course markers
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Year: 2022 PMID： 35622261 PMCID： PMC9136801 DOI： 10.1007/s10517-022-05490-7
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.737