Literature DB >> 35622253

Synergy between the Levels of Methylation of microRNA Gene Sets in Primary Tumors and Metastases of Ovarian Cancer Patients.

S S Lukina1, A M Burdennyy2, E A Filippova1, I V Pronina1, N A Ivanova1, T P Kazubskaya3, D N Kushlinskii3, D O Utkin3, V I Loginov1, E A Braga1, N E Kushlinskii3.   

Abstract

We studied the correlations between the levels of methylation of a group of 21 microRNA genes in 99 primary tumors and 29 macroscopic peritoneal metastases of ovarian cancer. Analysis of the level of methylation by quantitative methylation-specific PCR showed that co-methylation was detected for 13 pairs of microRNA genes in primary tumors and for 22 pairs in metastases. Pairs of microRNA genes that have shown significant co-methylation can be involved in common processes and pathways of gene regulation and interaction and can have common target genes. The results are highly significant and pairs of microRNA genes can be proposed as new potential markers for the diagnosis and prognosis of ovarian cancer metastasis.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  microRNA genes; ovarian cancer; peritoneal metastases; primary tumors; synergism

Mesh：

Substances：

Year:  2022        PMID： 35622253     DOI： 10.1007/s10517-022-05499-y

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

1.  WeCoMXP: Weighted Connectivity Measure Integrating Co-Methylation, Co-Expression and Protein-Protein Interactions for Gene-Module Detection.

Authors:  Saurav Mallik; Sanghamitra Bandyopadhyay
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2018-09-03       Impact factor: 3.710

2.  [Novel miRNA genes hypermethylated in breast cancer].

Authors:  V I Loginov; A M Burdennyy; I V Pronina; V V Khokonova; S V Kurevljov; T P Kazubskaya; N E Kushlinskii; E A Braga
Journal:  Mol Biol (Mosk)       Date:  2016 Sep-Oct

3.  DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.

Authors:  Irina V Pronina; Vitaly I Loginov; Alexey M Burdennyy; Marina V Fridman; Vera N Senchenko; Tatiana P Kazubskaya; Nikolay E Kushlinskii; Alexey A Dmitriev; Eleonora A Braga
Journal:  Gene       Date:  2016-12-18       Impact factor: 3.688

4.  [Clinical significance of methylation of a group of miRNA genes in patients with ovarian cancer.]

Authors:  N E Kushlinskii; D O Utkin; V I Loginov; E A Filippova; A M Burdennyy; D N Kushlinsky; I V Pronina; E A Braga
Journal:  Klin Lab Diagn       Date:  2020

5.  Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers.

Authors:  Maria Panagopoulou; Makrina Karaglani; Ioanna Balgkouranidou; Eirini Biziota; Triantafillia Koukaki; Evaggelos Karamitrousis; Evangelia Nena; Ioannis Tsamardinos; George Kolios; Evi Lianidou; Stylianos Kakolyris; Ekaterini Chatzaki
Journal:  Oncogene       Date:  2019-01-14       Impact factor: 9.867

6.  A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.

Authors:  Kirsten Hattermann; H Maximilian Mehdorn; Rolf Mentlein; Susann Schultka; Janka Held-Feindt
Journal:  Anal Biochem       Date:  2008-03-14       Impact factor: 3.365

7.  Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer.

Authors:  Vera N Senchenko; Ekaterina A Anedchenko; Tatiana T Kondratieva; George S Krasnov; Alexei A Dmitriev; Veronika I Zabarovska; Tatiana V Pavlova; Vladimir I Kashuba; Michael I Lerman; Eugene R Zabarovsky
Journal:  BMC Cancer       Date:  2010-03-01       Impact factor: 4.430

8.  Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis.

Authors:  Vitaly I Loginov; Irina V Pronina; Alexey M Burdennyy; Elena A Filippova; Tatiana P Kazubskaya; Dmitry N Kushlinsky; Dmitry O Utkin; Dmitry S Khodyrev; Nikolay E Kushlinskii; Alexey A Dmitriev; Eleonora A Braga
Journal:  Gene       Date:  2018-04-06       Impact factor: 3.688

9.  Molecular signatures identified by integrating gene expression and methylation in non-seminoma and seminoma of testicular germ cell tumours.

Authors:  Saurav Mallik; Guimin Qin; Peilin Jia; Zhongming Zhao
Journal:  Epigenetics       Date:  2020-07-13       Impact factor: 4.528

10.  Pan-cancer analysis of frequent DNA co-methylation patterns reveals consistent epigenetic landscape changes in multiple cancers.

Authors:  Jie Zhang; Kun Huang
Journal:  BMC Genomics       Date:  2017-01-25       Impact factor: 3.969
  10 in total

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