Fatih Celik1, Ebru Coteli2, Fatih Cem Gul1, Ercan Ozsoy3, Sabiha Gungor Kobat1, Zuhal Karaca Karagoz4, Suna Aydin5,6, Kader Ugur7, Meltem Yardim8, İbrahim Sahin9,10, Mehmet Hanifi Yalcin11, Ramazan Fazil Akkoc6, Suleyman Aydin12. 1. Department of Ophthalmology, Elazig Fethi Sekin City Hospital, Health Science University, Elazig Campus, Elazig, Turkey. 2. Health Services Vocational School, Ahi Evran University, Kirsehir, Turkey. 3. Department of Ophthalmology, Haseki Education Research Hospital, Istanbul, Turkey. 4. Department of Internal Medicine (Endocrine and Metabolism Disease), Elazig Fethi Sekin City Hospital, Health Science University, Elazig Campus, Elazig, Turkey. 5. Department of Cardiovascular Surgery, Elazig Fethi Sekin City Hospital, Health Science University, Elazig Campus, Elazig, Turkey. 6. Department of Anatomy, Medical School, Firat University, Elazig, Turkey. 7. Department of Internal Medicine (Endocrine and Metabolism Disease), Medical School, Firat University, Elazig, Turkey. 8. Department of Medical Biochemistry, Yerköy State Hospital, Yozgat, Turkey. 9. Department of Medical Biology, Medical School, Erzincan Binali Yildirim University, Erzincan, Turkey. 10. Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Medical School, Firat University, Elazig, Turkey. 11. Department of Histology and Embryology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey. 12. Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Medical School, Firat University, Elazig, Turkey. saydin1@hotmail.com.
Abstract
PURPOSE: The molecules human interleukin (IL-18), the soluble cluster of differentiation (sCD40), platelet factor 4 variant 1 (PF4V1), and neutrophil gelatinase-associated lipocalin (NGAL) are all markers of inflammation in biological systems and are linked to prognosis in several inflammatory diseases as well. Since there is no study in which the above-mentioned molecules are studied together in ocular Behçet's disease (OBD), the aim of this study is to reveal whether these molecules are activity markers in active (OABD) and inactive (OIBD) disease. METHODS: 30 OABD and 30 OIBD and 30 healthy individuals were included in the study. IL-18, sCD40, PF4V1, and NGAL molecules were studied in blood samples by the ELISA method. RESULTS: When OABD and OIBD were compared to healthy individuals, the levels of IL-18, sCD40, PF4V1, and NGAL molecules were found to be statistically significant. These values were even more significantly higher in patients with OABD. CONCLUSION: When ROC values of IL-18, sCD40, PF4V1, and NGAL are evaluated, it is clear that these four molecules can be used as biomarkers to aid activity and diagnosis in OBD.
PURPOSE: The molecules human interleukin (IL-18), the soluble cluster of differentiation (sCD40), platelet factor 4 variant 1 (PF4V1), and neutrophil gelatinase-associated lipocalin (NGAL) are all markers of inflammation in biological systems and are linked to prognosis in several inflammatory diseases as well. Since there is no study in which the above-mentioned molecules are studied together in ocular Behçet's disease (OBD), the aim of this study is to reveal whether these molecules are activity markers in active (OABD) and inactive (OIBD) disease. METHODS: 30 OABD and 30 OIBD and 30 healthy individuals were included in the study. IL-18, sCD40, PF4V1, and NGAL molecules were studied in blood samples by the ELISA method. RESULTS: When OABD and OIBD were compared to healthy individuals, the levels of IL-18, sCD40, PF4V1, and NGAL molecules were found to be statistically significant. These values were even more significantly higher in patients with OABD. CONCLUSION: When ROC values of IL-18, sCD40, PF4V1, and NGAL are evaluated, it is clear that these four molecules can be used as biomarkers to aid activity and diagnosis in OBD.