Nilay Aksoy1, Emine Sen2, Susi Sukmasari3, Özlem Bingöl Özakpınar4, Feyze Arıcıoğlu5, Yasemin Yücel Yücel2, Muhammet Rıdvan Dumlu6, Abd Almonem Doolaanea7, Mohammad Nasrin AbdulRahman8, Vakur Olgac9, Pırıl Bozkan10, Bugra Ozen10,11. 1. School of Pharmacy, Department of Clinical Pharmacy, Altınbaş University, Zuhuratbaba, Incirli Cd. No:11-A, 34147, Istanbul, Turkey. nilay.aksoy@altinbas.edu.tr. 2. School of Pharmacy, Department of Biochemistry, Altınbaş University, Istanbul, Turkey. 3. Pediatric Dentistry Department and Dental Public Health Department, International Islamic University Malaysia, Kuantan, Malaysia. 4. School of Pharmacy, Department of Biochemistry, Marmara University, Istanbul, Turkey. 5. Institute of Health Sciences, Marmara University, Istanbul, Turkey. 6. Department of Infectious Disease and Clinical Microbiology, University of Health Sciences, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Turkey. 7. Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University, Kuantan, Malaysia. 8. Faculty of Pharmacy, PICOMS International University College, Kuala Lumpur, Malaysia. 9. Institute of Oncology, Department of Tumor Pathology, Istanbul University, Istanbul, Turkey. 10. Department of Pediatric Dentistry, Faculty of Dentistry, Altınbaş University, Istanbul, Turkey. 11. Department of Pediatric Dentistry, Faculty of Dentistry, Istanbul Health and Technology University, Istanbul, Turkey.
Abstract
PURPOSE: The study aimed to evaluate the possible preventive effect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. METHOD: Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the fifth day of the study, the cheek and sublingual mucosa were irritated by external superficial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. RESULTS: The weight and the mucositis scores were recorded. Antioxidant and anti-inflammatory markers and biochemical tests were analyzed. Significant differences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-inflammatory parameters. CONCLUSION: The preventive effect of 3% gel was significant, with no mortality rate, making it an option for preventive strategies.
PURPOSE: The study aimed to evaluate the possible preventive effect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. METHOD: Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the fifth day of the study, the cheek and sublingual mucosa were irritated by external superficial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. RESULTS: The weight and the mucositis scores were recorded. Antioxidant and anti-inflammatory markers and biochemical tests were analyzed. Significant differences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-inflammatory parameters. CONCLUSION: The preventive effect of 3% gel was significant, with no mortality rate, making it an option for preventive strategies.
Authors: Richard M Logan; Andrea M Stringer; Joanne M Bowen; Rachel J Gibson; Stephen T Sonis; Dorothy M K Keefe Journal: Cancer Biol Ther Date: 2008-04-29 Impact factor: 4.742
Authors: Claudio Pulito; Antonio Cristaudo; Caterina La Porta; Stefano Zapperi; Giovanni Blandino; Aldo Morrone; Sabrina Strano Journal: J Exp Clin Cancer Res Date: 2020-10-07