Literature DB >> 35616790

Antiplatelet Activity of Riamilovir under Conditions of Lipopolysaccharide Intoxication.

A A Spasov1, A F Kucheryavenko2, V S Sirotenko1, K A Gaidukova1, G M Uskov1.   

Abstract

We studied the effect of antiviral agent riamilovir on ADP-induced platelet aggregation in the absence and presence of LPS. Unlike acetylsalicylic acid (reference drug), riamilovir did not exhibit antiplatelet effect in vitro. However, it markedly suppressed platelet reactivity in LPS-treated blood samples and was 2.2-fold superior to acetylsalicylic acid in terms of IC50 value. In in vivo experiments, riamilovir under conditions of hypercytokinemia blocked platelet aggregation in rats by 64%.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  LPS; hypercytokinemia; platelet aggregation; riamilovir

Mesh：

Substances：

Year:  2022        PMID： 35616790      PMCID： PMC9134143          DOI： 10.1007/s10517-022-05489-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  10 in total

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Authors:  Alexander Zarbock; Renata K Polanowska-Grabowska; Klaus Ley
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2.  Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice.

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Journal:  Pulm Pharmacol Ther       Date:  2017-05-06       Impact factor: 3.410

3.  Platelets and Immunity: Going Viral.

Authors:  Milka Koupenova; Jane E Freedman
Journal:  Arterioscler Thromb Vasc Biol       Date:  2020-06-24       Impact factor: 8.311

4.  The role of platelets in mediating a response to human influenza infection.

Authors:  Milka Koupenova; Heather A Corkrey; Olga Vitseva; Giorgia Manni; Catherine J Pang; Lauren Clancy; Chen Yao; Jeffrey Rade; Daniel Levy; Jennifer P Wang; Robert W Finberg; Evelyn A Kurt-Jones; Jane E Freedman
Journal:  Nat Commun       Date:  2019-04-16       Impact factor: 14.919

5.  SARS-CoV-2 and viral sepsis: observations and hypotheses.

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Journal:  Lancet       Date:  2020-04-17       Impact factor: 79.321

6.  COVID-19: the vasculature unleashed.

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Journal:  Nat Rev Immunol       Date:  2020-07       Impact factor: 53.106

7.  Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.

Authors:  Hui Qun Fu; Ting Yang; Wei Xiao; Long Fan; Yan Wu; Niccolò Terrando; Tian Long Wang
Journal:  PLoS One       Date:  2014-08-29       Impact factor: 3.240

8.  Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling.

Authors:  Maria E Lopes Pires; Simon R Clarke; Sisi Marcondes; Jonathan M Gibbins
Journal:  PLoS One       Date:  2017-11-14       Impact factor: 3.240

9.  Platelet gene expression and function in patients with COVID-19.

Authors:  Bhanu Kanth Manne; Frederik Denorme; Elizabeth A Middleton; Irina Portier; Jesse W Rowley; Chris Stubben; Aaron C Petrey; Neal D Tolley; Li Guo; Mark Cody; Andrew S Weyrich; Christian C Yost; Matthew T Rondina; Robert A Campbell
Journal:  Blood       Date:  2020-09-10       Impact factor: 25.476

10.  Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19.

Authors:  Eugenio D Hottz; Isaclaudia G Azevedo-Quintanilha; Lohanna Palhinha; Lívia Teixeira; Ester A Barreto; Camila R R Pão; Cassia Righy; Sérgio Franco; Thiago M L Souza; Pedro Kurtz; Fernando A Bozza; Patrícia T Bozza
Journal:  Blood       Date:  2020-09-10       Impact factor: 22.113
  10 in total
  1 in total

1.  Development of Drugs with Direct Antiviral Action Based on Azaheterocyclic Systems.

Authors:  V N Charushin; V L Rusinov; M V Varaksin; O N Chupakhin; O P Kovtun; A A Spasov
Journal:  Her Russ Acad Sci       Date:  2022-09-06       Impact factor: 0.552
  1 in total

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