Literature DB >> 35610421

Cell-Based Phenotypic Screens to Discover Circadian Clock-Modulating Compounds.

Megumi Hatori1, Tsuyoshi Hirota2.   

Abstract

There is increasing demand to control circadian clock functions in a conditional manner for deeper understanding of the circadian system as well as for potential treatment of clock-related diseases. Small-molecule compounds provide powerful tools to reveal novel functions of target proteins in the circadian clock mechanism, and can be great therapeutic candidates. Here we describe the detailed methods of measuring cellular circadian rhythms in a high-throughput manner for chemical screening to identify compounds that affect circadian rhythms by targeting clock-related proteins.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Cell-based phenotypic screen; Circadian clock; High-throughput screening; Luciferase reporter; Period; Small-molecule compounds

Mesh：

Substances：

Year:  2022        PMID： 35610421     DOI： 10.1007/978-1-0716-2249-0_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  37 in total

Review 1.  Molecular spies for bioimaging--fluorescent protein-based probes.

Authors:  Atsushi Miyawaki; Yusuke Niino
Journal:  Mol Cell       Date:  2015-05-21       Impact factor: 17.970

2.  Synchronous circadian voltage rhythms with asynchronous calcium rhythms in the suprachiasmatic nucleus.

Authors:  Ryosuke Enoki; Yoshiaki Oda; Michihiro Mieda; Daisuke Ono; Sato Honma; Ken-Ichi Honma
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-07       Impact factor: 11.205

Review 3.  Pharmacological Interventions to Circadian Clocks and Their Molecular Bases.

Authors:  Simon Miller; Tsuyoshi Hirota
Journal:  J Mol Biol       Date:  2020-01-10       Impact factor: 5.469

4.  Coupling delay controls synchronized oscillation in the segmentation clock.

Authors:  Kumiko Yoshioka-Kobayashi; Marina Matsumiya; Yusuke Niino; Akihiro Isomura; Hiroshi Kori; Atsushi Miyawaki; Ryoichiro Kageyama
Journal:  Nature       Date:  2020-01-08       Impact factor: 49.962

5.  Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic nucleus neurons.

Authors:  Masayuki Ikeda; Takashi Sugiyama; Christopher S Wallace; Heinrich S Gompf; Tohru Yoshioka; Atsushi Miyawaki; Charles N Allen
Journal:  Neuron       Date:  2003-04-24       Impact factor: 17.173

6.  Constant light desynchronizes mammalian clock neurons.

Authors:  Hidenobu Ohta; Shin Yamazaki; Douglas G McMahon
Journal:  Nat Neurosci       Date:  2005-01-30       Impact factor: 24.884

Review 7.  Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems.

Authors:  Zheng Chen; Seung-Hee Yoo; Joseph S Takahashi
Journal:  Annu Rev Pharmacol Toxicol       Date:  2017-10-02       Impact factor: 13.820

Review 8.  Transcriptional architecture of the mammalian circadian clock.

Authors:  Joseph S Takahashi
Journal:  Nat Rev Genet       Date:  2016-12-19       Impact factor: 53.242

9.  Lhx1 maintains synchrony among circadian oscillator neurons of the SCN.

Authors:  Megumi Hatori; Shubhroz Gill; Ludovic S Mure; Martyn Goulding; Dennis D M O'Leary; Satchidananda Panda
Journal:  Elife       Date:  2014-07-17       Impact factor: 8.140

10.  Output from VIP cells of the mammalian central clock regulates daily physiological rhythms.

Authors:  Sarika Paul; Lydia Hanna; Court Harding; Edward A Hayter; Lauren Walmsley; David A Bechtold; Timothy M Brown
Journal:  Nat Commun       Date:  2020-03-19       Impact factor: 14.919
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  1 in total

1.  A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins.

Authors:  Moeri Yagi; Simon Miller; Yoshiko Nagai; Shinsuke Inuki; Ayato Sato; Tsuyoshi Hirota
Journal:  F1000Res       Date:  2022-09-07
  1 in total

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