Haoyi Fu1, Nicola L Hawley2, Jenna C Carlson3, Emily M Russell4, Alysa Pomer5, Hong Cheng6, Take Naseri7, Muagututi'a Sefuiva Reupena8, Ranjan Deka6, Courtney C Choy2, Stephen T McGarvey9, Ryan L Minster4, Daniel E Weeks10. 1. Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 2. International Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Department of Epidemiology (Chronic Disease), School of Public Health, Yale University, New Haven, CT, USA. 3. Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 4. Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 5. Department of Anthropology, Yale University, New Haven, CT, USA. 6. Department of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. 7. International Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Ministry of Health, Apia, Samoa. 8. Lutia i Puava ae Mapu i Fagalele, Apia, Samoa. 9. International Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Department of Anthropology, Brown University, Providence, RI, USA. 10. Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: weeks@pitt.edu.
Abstract
OBJECTIVE: A missense variant, rs373863828, in CREBRF is associated with obesity in Polynesians. We investigate whether rs373863828 and other factors are associated with body mass index (BMI) rate-of-change between 2010 and 2017-19 in Samoans. METHODS: We used sex-stratified models to test whether BMI rate-of-change was associated with rs373863828, baseline BMI, age, residence, physical activity, and household asset score in a cohort study of 480 Samoan adults measured in both 2010 (mean age 43.8 years) and 2017-19. RESULTS: Mean BMI increased from 32.1 to 33.5 kg/m2 in males (n = 220, p = 1.3 ×10-8) and from 35.9 to 37.8 kg/m2 in females (n = 260, p = 1.2 ×10-13). In females, the A allele was associated with a higher rate-of-change (0.150 kg/m2/year/allele, p = 1.7 ×10-4). Across 10-year age groups, mean BMI rate-of-change was lower in older participants. The BMI rate of change differed by genotype: it was, in females with AA genotype, approximately half that seen in GG and AG participants. In females lower baseline household asset scores were associated with a higher rate-of-change (p = 0.002). CONCLUSIONS: In Samoans, the minor A allele of rs373863828 is associated with an increased rate-of-change in BMI in females. On average, BMI of females with the AA genotype increased 0.30 kg/m2/year more than of those with the GG genotype.
OBJECTIVE: A missense variant, rs373863828, in CREBRF is associated with obesity in Polynesians. We investigate whether rs373863828 and other factors are associated with body mass index (BMI) rate-of-change between 2010 and 2017-19 in Samoans. METHODS: We used sex-stratified models to test whether BMI rate-of-change was associated with rs373863828, baseline BMI, age, residence, physical activity, and household asset score in a cohort study of 480 Samoan adults measured in both 2010 (mean age 43.8 years) and 2017-19. RESULTS: Mean BMI increased from 32.1 to 33.5 kg/m2 in males (n = 220, p = 1.3 ×10-8) and from 35.9 to 37.8 kg/m2 in females (n = 260, p = 1.2 ×10-13). In females, the A allele was associated with a higher rate-of-change (0.150 kg/m2/year/allele, p = 1.7 ×10-4). Across 10-year age groups, mean BMI rate-of-change was lower in older participants. The BMI rate of change differed by genotype: it was, in females with AA genotype, approximately half that seen in GG and AG participants. In females lower baseline household asset scores were associated with a higher rate-of-change (p = 0.002). CONCLUSIONS: In Samoans, the minor A allele of rs373863828 is associated with an increased rate-of-change in BMI in females. On average, BMI of females with the AA genotype increased 0.30 kg/m2/year more than of those with the GG genotype.
Authors: Ryan L Minster; Nicola L Hawley; Chi-Ting Su; Guangyun Sun; Erin E Kershaw; Hong Cheng; Olive D Buhule; Jerome Lin; Muagututi'a Sefuiva Reupena; Satupa'itea Viali; John Tuitele; Take Naseri; Zsolt Urban; Ranjan Deka; Daniel E Weeks; Stephen T McGarvey Journal: Nat Genet Date: 2016-07-25 Impact factor: 38.330
Authors: S Lin; T Naseri; C Linhart; S Morrell; R Taylor; S T McGarvey; D J Magliano; P Zimmet Journal: Diabet Med Date: 2016-08-25 Impact factor: 4.359