Literature DB >> 35605036

Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure.

Andrew A Gibb1, Emma K Murray1, Anh T Huynh1, Ryan B Gaspar, Tori L Ploesch, Ken Bedi2, Alyssa A Lombardi1, Pawel K Lorkiewicz3, Rajika Roy1, Zolt Arany2, Daniel P Kelly2, Kenneth B Margulies2, Bradford G Hill4, John W Elrod1.   

Abstract

Entities:  

Keywords:  fibrosis; glutamine; heart failure; metabolism; myofibroblasts

Mesh：

Year:  2022        PMID： 35605036      PMCID： PMC9179236          DOI： 10.1161/CIRCULATIONAHA.121.057879

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   39.918


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  5 in total

Review 1.  Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation.

Authors:  Andrew A Gibb; Michael P Lazaropoulos; John W Elrod
Journal:  Circ Res       Date:  2020-07-16       Impact factor: 17.367

2.  The effect of metabolic acidosis on the synthesis and turnover of rat renal phosphate-dependent glutaminase.

Authors:  J Tong; G Harrison; N P Curthoys
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

3.  Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice.

Authors:  Susana Mingote; Justine Masson; Celia Gellman; Gretchen M Thomsen; Chyuan-Sheng Lin; Robert J Merker; Inna Gaisler-Salomon; Yvonne Wang; Rachel Ernst; René Hen; Stephen Rayport
Journal:  Front Syst Neurosci       Date:  2016-01-08

4.  Genetic lineage tracing defines myofibroblast origin and function in the injured heart.

Authors:  Onur Kanisicak; Hadi Khalil; Malina J Ivey; Jason Karch; Bryan D Maliken; Robert N Correll; Matthew J Brody; Suh-Chin J Lin; Bruce J Aronow; Michelle D Tallquist; Jeffery D Molkentin
Journal:  Nat Commun       Date:  2016-07-22       Impact factor: 14.919

5.  Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Authors:  Alyssa A Lombardi; Andrew A Gibb; Ehtesham Arif; Devin W Kolmetzky; Dhanendra Tomar; Timothy S Luongo; Pooja Jadiya; Emma K Murray; Pawel K Lorkiewicz; György Hajnóczky; Elizabeth Murphy; Zoltan P Arany; Daniel P Kelly; Kenneth B Margulies; Bradford G Hill; John W Elrod
Journal:  Nat Commun       Date:  2019-10-04       Impact factor: 14.919
  5 in total

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