Akemi Kataoka1, Takayuki Ueno2, Hideko Yamauchi3, Natsue Uehiro2, Chikako Takahata2, Yoko Takahashi2, Eri Nakashima2, Akiko Ogiya2, Takehiko Sakai2, Dai Kitagawa4, Hidetomo Morizono2, Yumi Miyagi2, Takuji Iwase5, Atsuko Kitano6, Yumi Fukatsu7, Nobuko Tamura8, Junko Kawano9, Hiroko Bando10, Kentaro Tamaki11, Kyoko Shiota12, Miwa Ozawa13, Mariko Kobayashi14, Shinji Ohno2. 1. Department of Surgical Oncology, Breast Oncology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. akemi.kataoka@jfcr.or.jp. 2. Department of Surgical Oncology, Breast Oncology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. 3. Department of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan. 4. Department of Breast Surgical Oncology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan. 5. Department of Breast and Endocrine Surgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan. 6. Department of Medical Oncology, St. Luke's International Hospital, Tokyo, Japan. 7. Department of Surgery, Kasukabe Medical Center, Saitama, Japan. 8. Department of Breast Surgical Oncology, Toranomon Hospital, Tokyo, Japan. 9. Department of Breast and Thyroid Surgical Oncology, Sagara Hospital, Kagoshima, Japan. 10. Breast and Endocrine Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. 11. Department of Breast Surgery, Nahanishi Clinic, Okinawa, Japan. 12. Integrated Woman's Health, St. Luke's International Hospital, Tokyo, Japan. 13. Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan. 14. The Open University of Japan, Chiba, Japan.
Abstract
PURPOSE: To clarify the characteristics, treatment trends, and long-term outcomes of patients with pregnancy-associated breast cancer (PABC). METHODS: PABC includes breast cancer diagnosed during pregnancy (PBC) and breast cancer diagnosed within 1 year after childbirth or during lactation (LBC). We compared clinical characteristics of 126 patients with LBC and 49 patients with PBC who underwent surgery at our hospital from 1946 to 2018. Survival was compared between patients with LBC and those with PBC in terms of breast cancer-specific disease-free survival (BC-DFS) and overall survival (OS). RESULTS: Patients with LBC were more likely to have family history, lymph node metastasis, lymphatic invasion, and to receive chemotherapy than patients with PBC. Patients with LBC showed poorer BS-DFS and OS than patients with PBC. Among patients with LBC, those treated after 2005 were older at surgery, had a smaller tumor size, received more systemic therapy, and had a more favorable prognosis than patients treated before 2004. Family history, breast cancer within 1 year after childbirth, and surgery before 2004 as well as cStage, lymph node metastasis, and lymphatic invasion were significantly associated with poor prognosis in patients with LBC. In the multivariate analysis for BC-DFS and OS among patients with PABC, LBC vs PBC did not remain as an independent prognostic factor while cStage remained. CONCLUSION: Patients with LBC had a poorer prognosis than those with PBC, most likely due to disease progression rather than biological characteristics. Early detection and optimization of systemic treatments are critical for improving the outcomes of patients with LBC.
PURPOSE: To clarify the characteristics, treatment trends, and long-term outcomes of patients with pregnancy-associated breast cancer (PABC). METHODS: PABC includes breast cancer diagnosed during pregnancy (PBC) and breast cancer diagnosed within 1 year after childbirth or during lactation (LBC). We compared clinical characteristics of 126 patients with LBC and 49 patients with PBC who underwent surgery at our hospital from 1946 to 2018. Survival was compared between patients with LBC and those with PBC in terms of breast cancer-specific disease-free survival (BC-DFS) and overall survival (OS). RESULTS: Patients with LBC were more likely to have family history, lymph node metastasis, lymphatic invasion, and to receive chemotherapy than patients with PBC. Patients with LBC showed poorer BS-DFS and OS than patients with PBC. Among patients with LBC, those treated after 2005 were older at surgery, had a smaller tumor size, received more systemic therapy, and had a more favorable prognosis than patients treated before 2004. Family history, breast cancer within 1 year after childbirth, and surgery before 2004 as well as cStage, lymph node metastasis, and lymphatic invasion were significantly associated with poor prognosis in patients with LBC. In the multivariate analysis for BC-DFS and OS among patients with PABC, LBC vs PBC did not remain as an independent prognostic factor while cStage remained. CONCLUSION: Patients with LBC had a poorer prognosis than those with PBC, most likely due to disease progression rather than biological characteristics. Early detection and optimization of systemic treatments are critical for improving the outcomes of patients with LBC.
Authors: Traci R Lyons; Jenean O'Brien; Virginia F Borges; Matthew W Conklin; Patricia J Keely; Kevin W Eliceiri; Andriy Marusyk; Aik-Choon Tan; Pepper Schedin Journal: Nat Med Date: 2011-08-07 Impact factor: 53.440
Authors: Hatem A Azim; Luigi Santoro; William Russell-Edu; George Pentheroudakis; Nicholas Pavlidis; Fedro A Peccatori Journal: Cancer Treat Rev Date: 2012-07-09 Impact factor: 12.111
Authors: Antonio C Wolff; M Elizabeth H Hammond; David G Hicks; Mitch Dowsett; Lisa M McShane; Kimberly H Allison; Donald C Allred; John M S Bartlett; Michael Bilous; Patrick Fitzgibbons; Wedad Hanna; Robert B Jenkins; Pamela B Mangu; Soonmyung Paik; Edith A Perez; Michael F Press; Patricia A Spears; Gail H Vance; Giuseppe Viale; Daniel F Hayes Journal: J Clin Oncol Date: 2013-10-07 Impact factor: 44.544