Antonio D'Alessio1,2, Claudia Angela Maria Fulgenzi1,3, David J Pinato1,4. 1. Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK. 2. Department of Biomedical Sciences, Humanitas University, Milan, Italy. 3. Division of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, Italy. 4. Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.