Literature DB >> 35600070

Animal models of age-related macular degeneration and their translatability into the clinic.

Shida Chen1,2, Nicholas A Popp1, Chi-Chao Chan1.   

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in people over the age of 55. Despite its common nature, the etiology of the disease involves both genetic and environmental factors, the interaction of which is not fully understood. Animal models, including the mouse, rat, rabbit, pig and non-human primate, have been developed to study various aspects of the disease and to evaluate novel therapies; however, no single model has been developed to emulate all aspects of the disease. This review will discuss the various existing models of AMD, their strengths and limitations and examples of their use in current AMD research.

Entities:  

Keywords:  age-related macular degeneration; animal model; mouse; non-human primate; pathology; pig; rabbit; rat; therapy

Year:  2014        PMID： 35600070      PMCID： PMC9119377          DOI： 10.1586/17469899.2014.939171

Source DB:  PubMed          Journal:  Expert Rev Ophthalmol        ISSN： 1746-9899


  97 in total

1.  Age related macular degeneration in monozygotic twins and their spouses in Iceland.

Authors:  M S Gottfredsdottir; T Sverrisson; D C Musch; E Stefánsson
Journal:  Acta Ophthalmol Scand       Date:  1999-08

2.  Time-course of experimental choroidal neovascularization in Dutch-Belted rabbit: clinical and histological evaluation.

Authors:  Ming Ni; Michael Holland; Hilde Jarstadmarken; Gerald De Vries
Journal:  Exp Eye Res       Date:  2005-09       Impact factor: 3.467

Review 3.  Animal models of human disease: challenges in enabling translation.

Authors:  Paul McGonigle; Bruce Ruggeri
Journal:  Biochem Pharmacol       Date:  2013-08-14       Impact factor: 5.858

4.  Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey.

Authors:  Deeba Husain; Ivana Kim; Danny Gauthier; Anne Marie Lane; Miltiadis K Tsilimbaris; Eric Ezra; Edward J Connolly; Norman Michaud; Evangelos S Gragoudas; Charles A O'Neill; Joseph C Beyer; Joan W Miller
Journal:  Arch Ophthalmol       Date:  2005-04

5.  Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes.

Authors:  Marianne Berdugo; Riad A Bejjani; Fatemeh Valamanesh; Michele Savoldelli; Jean-Claude Jeanny; Dominique Blanc; Herve Ficheux; Avigdor Scherz; Yoram Salomon; David BenEzra; Francine Behar-Cohen
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-04       Impact factor: 4.799

6.  Drusenoid maculopathy in rhesus monkeys: autofluorescence, lipofuscin and drusen pathogenesis.

Authors:  Peter Gouras; Lena Ivert; Julie A Mattison; Donald K Ingram; Martha Neuringer
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-08-12       Impact factor: 3.117

Review 7.  Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.

Authors:  Anand Swaroop; Emily Y Chew; Catherine Bowes Rickman; Gonçalo R Abecasis
Journal:  Annu Rev Genomics Hum Genet       Date:  2009       Impact factor: 8.929

8.  Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.

Authors:  Peter J Coffey; Carlos Gias; Caroline J McDermott; Peter Lundh; Matthew C Pickering; Charanjit Sethi; Alan Bird; Fred W Fitzke; Annelie Maass; Li Li Chen; Graham E Holder; Philip J Luthert; Thomas E Salt; Stephen E Moss; John Greenwood
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-05       Impact factor: 11.205

9.  Association of HTRA1 and ARMS2 gene variation with drusen formation in rhesus macaques.

Authors:  Krishna K Singh; Michael Krawczak; William W Dawson; Joerg Schmidtke
Journal:  Exp Eye Res       Date:  2008-11-05       Impact factor: 3.467

10.  Age-related retinopathy in NRF2-deficient mice.

Authors:  Zhenyang Zhao; Yan Chen; Jian Wang; Paul Sternberg; Michael L Freeman; Hans E Grossniklaus; Jiyang Cai
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240
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  1 in total

1.  In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography.

Authors:  Ratheesh K Meleppat; Christopher R Fortenbach; Yifan Jian; Esteban Soto Martinez; Karen Wagner; Bobeck S Modjtahedi; Monica J Motta; Deepa L Ramamurthy; Ivan R Schwab; Robert J Zawadzki
Journal:  Transl Vis Sci Technol       Date:  2022-08-01       Impact factor: 3.048
  1 in total

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