Literature DB >> 3559296

A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments.

K Hynynen, R Roemer, D Anhalt, C Johnson, Z X Xu, W Swindell, T Cetas.   

Abstract

A commercial diagnostic ultrasound scanner (Octoson) was modified for performing hyperthermia treatments. The temperature elevations were induced in tissues by four large, focused ultrasonic transducers whose common focal zone was scanned along a computer controlled path as determined from B-scan images. The system is described and the results of preliminary tests demonstrating some of its capabilities are given. Extensive tests with canine thighs and kidneys were performed. The blood flow to the kidneys was controllable, and thus tumours having different blood perfusion rates could be simulated. The results showed that the system is capable of inducing a local temperature maximum deep in tissues (up to 10 cm was tested) and that tissues with high perfusion rates could be heated.

Entities:  

Mesh:

Year:  1987        PMID: 3559296     DOI: 10.3109/02656738709140370

Source DB:  PubMed          Journal:  Int J Hyperthermia        ISSN: 0265-6736            Impact factor:   3.914


  5 in total

1.  Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial.

Authors:  A N Guthkelch; L P Carter; J R Cassady; K H Hynynen; R P Iacono; P C Johnson; E A Obbens; R B Roemer; J F Seeger; D S Shimm
Journal:  J Neurooncol       Date:  1991-06       Impact factor: 4.130

Review 2.  MRI-guided monitoring of thermal dose and targeted drug delivery for cancer therapy.

Authors:  Ruchika Fernando; Jon Downs; Danny Maples; Ashish Ranjan
Journal:  Pharm Res       Date:  2013-06-19       Impact factor: 4.200

3.  An open environment CT-US fusion for tissue segmentation during interventional guidance.

Authors:  Charles F Caskey; Mario Hlawitschka; Shengping Qin; Lisa M Mahakian; Robert D Cardiff; John M Boone; Katherine W Ferrara
Journal:  PLoS One       Date:  2011-11-23       Impact factor: 3.240

4.  Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma.

Authors:  Giovanni Borasi; Alan Nahum; Margarethus M Paulides; Gibin Powathil; Giorgio Russo; Laura Fariselli; Debora Lamia; Roberta Cirincione; Giusi Irma Forte; Cristian Borrazzo; Barbara Caccia; Elisabetta di Castro; Silvia Pozzi; Maria Carla Gilardi
Journal:  J Ther Ultrasound       Date:  2016-12-08

Review 5.  Quality assurance guidelines for superficial hyperthermia clinical trials : II. Technical requirements for heating devices.

Authors:  Hana Dobšíček Trefná; Johannes Crezee; Manfred Schmidt; Dietmar Marder; Ulf Lamprecht; Michael Ehmann; Jacek Nadobny; Josefin Hartmann; Nicolleta Lomax; Sultan Abdel-Rahman; Sergio Curto; Akke Bakker; Mark D Hurwitz; Chris J Diederich; Paul R Stauffer; Gerard C Van Rhoon
Journal:  Strahlenther Onkol       Date:  2017-03-01       Impact factor: 3.621

  5 in total

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